Investigating pathways involved in liver disease related to alcohol use
Targeting PI3K/BRD4 and Hedgehog Pathway in Alcohol Associated Liver Disease
This study is looking at how specific cellular pathways related to alcohol use can cause liver damage and inflammation, with the goal of finding new treatments that could help people with alcohol-related liver disease feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project ID | NIH-11135983 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain cellular pathways, specifically the PI3K/BRD4 and Hedgehog pathways, contribute to liver disease caused by alcohol consumption. The study aims to explore how these pathways interact and lead to inflammation and liver damage. By targeting these pathways, the research seeks to develop new therapeutic strategies that could improve outcomes for individuals suffering from alcohol-associated liver disease. Patients may benefit from advancements in treatment options that arise from this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease or those experiencing liver complications due to alcohol use.
Not a fit: Patients with liver disease not related to alcohol consumption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve liver health for patients with alcohol-related liver disease.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for liver diseases, indicating potential for success in this approach.
Where this research is happening
Toledo, United States
- University of Toledo Health Sci Campus — Toledo, United States (Active)
Researchers
- Principal investigator: Kumar, Virender — University of Toledo Health Sci Campus
- Study coordinator: Kumar, Virender
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.