How changes in tRNA affect aging processes
Official title: Mechanistic tRNA modification affects to aging
Funded at University of Toledo Health Sci Campus · NIH-11039136 · Data updated 2026-11-12
This study is looking at how changes in a special type of molecule called tRNA, which helps make proteins in our cells, might affect how we age and contribute to diseases like heart problems, diabetes, and cancer, especially when our cells are under stress.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo Health Sci Campus NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | November 15, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $430,603 |
| NIH project number | 1R21AG091047-01 |
| Project ID | NIH-11039136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing age-related health issues.
✕Less likely to help
Patients under the age of 65 or those without age-related health conditions may not benefit from this research.
What this research studies
This research investigates the role of tRNA modifications in the aging process, particularly how these changes can influence protein translation and cellular function. By examining the biochemical alterations in tRNA that occur with age, the study aims to uncover mechanisms that contribute to age-related diseases such as cardiovascular disease, diabetes, and cancer. The researchers will focus on how oxidative stress impacts tRNA modifications and the subsequent effects on cellular health and aging. This work could lead to a better understanding of the biological processes that underlie aging and associated disorders.
Why it matters
Potential benefit: If successful, this research could provide insights into new therapeutic strategies for age-related diseases, potentially improving health outcomes for older adults.
How similar studies have gone: While the specific focus on tRNA modifications in aging is relatively novel, related research has shown promising results in understanding the role of cellular stress and protein translation in age-related diseases.
Where this research is happening
-
University of Toledo Health Sci Campus
Toledo, United States Active
Researchers
- Principal investigator: Prestwich, Erin G — University of Toledo Health Sci Campus
- Study coordinator: Prestwich, Erin G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.