Dissecting how TNBC tumors suppress the immune system using myeloid cells

Who could benefit from this research

What this research studies

The research focuses on triple-negative breast cancer, a challenging form of breast cancer that often resists common therapies. It studies how tumor TAZ influences immune cells in the tumor environment, including myeloid-derived suppressor cells and macrophages, using mouse models and human-derived data. By analyzing how TAZ affects immune suppression, the project aims to identify new ways to boost immune responses when combined with standard chemotherapy. The work involves preclinical experiments to understand the mechanisms and potential points to intervene in TNBC biology.

Why it matters

Where this research is happening

• University of Toledo Health Sci Campus
  Toledo, United States Active

Researchers

• Principal investigator: Zhang, Jianmin — University of Toledo Health Sci Campus
• Study coordinator: Zhang, Jianmin

Related research

Other NIH-funded projects on the same topics.

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• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

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  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

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  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.