Sponsor or institution
Clinical trials and research at Tufts Medical Center
As of November 12, 2026, Find a Trial lists 20 clinical trials run by Tufts Medical Center that are recruiting, in United States. By phase: Phase 3 (1), Phase 2 (1), Phase 1 (1). There are also 80 NIH-funded research projects at this institution, with $67.1 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 20Clinical trials
- 80NIH research projects
- 1Country
Newest trials
All recruiting trials (20)
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Personalized pacing for HFpEF patients with pacemakers
This study tests whether customizing heart-rate pacing (myPACE) in people with HFpEF and a pre-existing pacemaker can improve exercise ability and heart function.
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Sacituzumab tirumotecan with or without pembrolizumab in ovarian clear cell cancer that has come back or spread
This phase II study tests Sacituzumab tirumotecan alone or with pembrolizumab in adults whose ovarian clear cell cancer has recurred or spread after prior PD-1 therapy.
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Outcomes of Oncoplastic Breast Surgery and Goldilocks Mastectomy at Tufts Medicine
This study will look at past and future surgical results and patient satisfaction after oncoplastic breast surgery or Goldilocks mastectomy at Tufts Medicine to see how patients fare over time.
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Pulmonary embolism with right-to-left heart or lung shunts
This project will see if people with an acute pulmonary embolism who also have a right-to-left shunt (like a PFO or ASD) are more likely to have a stroke than PE patients without a shunt.
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Veverimer to reduce acid load and slow bone loss in adults with osteopenia
This trial will test whether taking veverimer, compared with placebo, lowers urinary acid levels and reduces bone breakdown in adults aged 50 and older with osteopenia.
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Vitamin D to Help Blood Sugar in People at Risk for Type 2 Diabetes
This study tests whether weekly vitamin D, adjusted to reach a target blood level, can help control blood sugar in adults with prediabetes.
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Real-time glucose monitoring with group support during pregnancy
This program will test whether wearing a real-time glucose monitor and joining a group chat helps pregnant people at risk for gestational diabetes keep their blood sugar in a healthy range.
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Music for people admitted to labor and delivery.
This trial will test whether listening to your preferred music for 10 minutes during labor can lower anxiety or pain and improve satisfaction.
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Using myo-inositol during pregnancy to prevent gestational diabetes
This study tests if taking myo-inositol during pregnancy can help prevent gestational diabetes in obese women.
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Remote Tai Chi for treating knee pain in osteoarthritis
This study is testing if remote Tai Chi sessions can help adults with knee osteoarthritis feel less pain and improve their quality of life compared to just routine care.
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Novel incubator pad for treating apnea in premature infants
This study is testing a new incubator pad that uses gentle vibrations to help preterm infants with apnea breathe better and need less medical support.
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Screening for AL Amyloidosis in patients with Smoldering Multiple Myeloma
This study is trying to find out if screening for a specific type of amyloidosis can help catch it early in patients with smoldering multiple myeloma before they show any symptoms.
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Assessing muscle thickness changes in heart failure patients
This study is testing how muscle thickness changes in heart failure patients receiving advanced treatments like heart transplants or assist devices to see how it affects their recovery.
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Using TENS units to reduce pain during IUD insertion
This study is testing if using TENS units can help reduce pain for women aged 12 to 50 during IUD insertion.
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Evaluating lung function in individuals with long-term effects of COVID-19
This study is trying to see how COVID-19 affects lung function in people who have ongoing symptoms, compared to those who didn’t have any symptoms.
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Dietary protein intervention for muscle recovery in heart failure patients
This study is testing if adding more protein to the diet can help heart failure patients keep their muscle mass and recover better.
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A nationwide registry for chronic kidney disease patients
This study is creating a detailed registry for people with chronic kidney disease, including those on dialysis or who have had a transplant, to help improve their care and support.
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Using a Pulmonary Artery Catheter to Improve Outcomes in Cardiogenic Shock
This study is testing if using a special heart monitoring device early on can help people with severe heart failure feel better and survive their hospital stay.
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Survey on barriers faced by minority anesthesiologists
This study is trying to find out what challenges minority anesthesiologists face in moving up to leadership roles by surveying their experiences and opinions.
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Registry for patients with cardiogenic shock
This study is gathering health information from patients with cardiogenic shock at different hospitals to help improve treatment and understanding of this serious condition.
NIH-funded research (newest 40 of 80)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Modeling to Prevent and Control Uterine Cancer
A national modeling effort uses computer simulations to inform better prevention, screening, and treatment of uterine cancer for women.
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Remote tai chi for knee OA in everyday care
A nationwide study will test remotely delivered tai chi for people with knee osteoarthritis to see if it helps pain and function when added to usual care.
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Comparative modeling to guide uterine cancer care
This grant uses computer models to help doctors and patients understand how to make better decisions about uterine cancer care.
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How eGFR drop after heart failure meds affects stopping those meds
A small NIH grant will look at whether stopping heart failure medicines after a kidney function drop is safe for patients with heart failure.
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Paid family leave and child well-being: new policy affects families and kids
A large study will look at whether paid family and medical leave helps prevent bad childhood experiences and promotes positive ones, especially in communities that often face inequities.
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Glycosylation and corneal nerve health
A scientists’ team at Tufts Medical Center is studying how sugars attached to proteins affect healing and feeling in the eye’s surface after injury.
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Innate immune control of abnormal retinal blood vessel growth
A new NIH grant looks at how the body's own immune signals drive or restrain abnormal blood vessel growth in the retina, a key factor in vision loss from conditions like retinopathy of prematurity.
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Rapid RNA-based test to guide antibiotics for tough lung bacteria (Mycobacterium abscessus)
A doctor might use a new quick RNA test to decide the best antibiotics for patients with lung infections caused by Mycobacterium abscessus.
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Veverimer to reduce acid in diet-related bone loss in adults with osteopenia
A medication called veverimer is being tested in adults with osteopenia to see if it helps reduce bone loss by neutralizing excess acid from the diet without causing extra sodium or potassium problems.
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Placental miRNAs and insulin sensitivity in pregnancy
This grant explores whether tiny molecules from the placenta help control how the mother’s body handles insulin during pregnancy, with potential implications for gestational diabetes.
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Endothelial Pannexin1 and Brain Inflammation in Alzheimer’s Disease
This project looks at how a channel in brain blood vessel cells may drive inflammation and worsen Alzheimer’s disease in people.
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Estrogen receptor alpha in smooth muscle and aging arteries
This NIH grant investigates how estrogen receptor alpha in artery walls affects aging-related stiffening, with a focus on differences between men and women.
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Role of blood vessel genes in vascular health and disease
This NIH grant supports building a patient-focused resource and lab models from people with peripheral artery disease to study how blood vessel genes affect blood flow and risk of amputation.
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Genomics of eye pressure and glaucoma risk
This NIH grant funds a short-term study to understand the genetic and cellular reasons behind high eye pressure and glaucoma, with potential to inform future treatments for people at risk.
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FHOD3 and autophagy in heart disease
A study in adults with hypertrophic heart changes to understand how FHOD3 affects heart cell recycling and could lead to new ways to treat cardiomyopathy.
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Artery cell channels and stroke-related dementia in older men and women
This work looks at whether blocking an artery-cell channel called Panx1 can help older men and women have less brain damage and dementia after an ischemic stroke.
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Circuit-based brain stimulation to help memory and mood in older adults with Alzheimer’s dementia
A new NIH project tests safe, multi-channel brain stimulation to improve memory and mood for older adults with mild Alzheimer’s-related dementia.
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MLK3 as a key mediator of PKG1 therapy in heart failure
A researcher is studying whether MLK3 helps PKG1-based treatments work better for people with heart failure.
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Nutrition and metabolism approach to prevent eye damage in premature babies
This project explores whether giving specific nutrients that support liver and retinal energy metabolism can help prevent or reduce eye damage in premature newborns.
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Virtual helpers and clear visuals to make cancer symptom reports easier to use
This project helps people with cancer use talking virtual agents and easy-to-read visuals so they can report symptoms and quality-of-life concerns more clearly.
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Checking for AL amyloidosis in people with smoldering myeloma
This project will use blood markers and clinical data to find hidden AL amyloidosis early in people with smoldering multiple myeloma.
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Combining international Hodgkin lymphoma data to understand long-term treatment effects
This project brings together trial and registry data to learn how treatments affect long-term health in adults with Hodgkin lymphoma.
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Finding hidden small strokes and white matter damage on routine brain scans with AI
Using artificial intelligence to spot unnoticed brain blood-vessel damage on routine CT or MRI scans to help people at risk for stroke and dementia.
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How nerves help keep the cornea clear and prevent abnormal blood vessel growth
This NIH grant explores how nerve signals in the cornea help keep it free of blood vessels and how nerve loss may cause vision problems, with potential treatments to protect vision.
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ACP Educator Video Program to Help Older Adults and Dementia Patients Align Care with What Matters
Aimed at helping older adults and people with Alzheimer's and related dementias plan ahead with doctors using friendly video decision aids and counselor support.
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Advancing Ethical Goals in Society: Implementation Core (care planning for Alzheimer's and related dementias)
A nationwide program tests long-term, multi-part strategies to help people with Alzheimer's and related dementias and their families make clearer, more goal-aligned medical decisions.
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Advancing Ethical Goals in End-of-Life Care for Alzheimer’s and Related Dementias
A federal grant is funding an ethics-focused project to improve end-of-life care and shared decision making for older adults with Alzheimer’s and related dementias, especially in rural communities.
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ACP Educator Video Program to Help Older Adults and ADRD Patients Align Care with Their Wishes
A national program uses short videos to help older people and those with dementia express and document their care wishes with their doctors and families.
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Video program to help older adults and those with Alzheimer's choose care that matches their values
A large, patient-facing program uses short videos to help people 65 and older, including those with Alzheimer’s and related dementias, make medical care decisions that fit their values and goals.
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Reducing galectin-3 to help corneal nerves heal
Looking at whether lowering the protein galectin-3 can help people with corneal nerve damage heal and regain eye sensation.
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Targeting angiogenin and plexin-B2 to help prevent glioblastoma from coming back
Researchers will block the protein plexin-B2 and its partner angiogenin to try to reduce therapy-resistant glioblastoma stem cells and delay tumor return in people with glioblastoma.
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Hormone receptor in artery muscle linked to obesity-related artery stiffness
This project explores how a hormone-activated receptor in artery muscle cells may make large blood vessels stiffer in people with obesity and how those effects differ between women and men.
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Imaging the heart's cell-cleanup process during chemotherapy that can harm the heart
A new nanoparticle imaging agent will be used to show when heart cells clear damaged material during cancer treatments that can injure the heart.
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Kidney tubule health and heart disease risk in middle-aged and older adults
This project uses urine markers of kidney tubule health to help identify middle-aged and older adults at higher risk for atherosclerotic heart disease and heart failure.
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Hypoxia and Eye Injury from Mustard Vesicants
This grant investigates how low oxygen levels worsen eye injuries caused by mustard chemicals and what can be done to protect vision.
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Remote Tai Chi for Knee Osteoarthritis
People with knee osteoarthritis are offered twice-weekly online Tai Chi for three months to reduce knee pain and improve daily function.
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How a specific protein affects heart muscle health and disease
This study is looking at how a protein called FHOD3 affects heart muscle cells and could help us understand and treat conditions like hypertrophic cardiomyopathy (HCM) by using special techniques to see how a specific gene change impacts heart health and cell repair.
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Mustard gas effects on the eye surface mitochondria
Researchers are testing small molecules that may protect the cells on the eye surface from damage caused by mustard gas and related chemicals, aiming to help people with chemical eye injuries.
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Using the immune system to control abnormal blood vessel growth in the retina
Seeing if changing innate immune signals can stop harmful new blood vessels that lead to vision loss in people with proliferative retinopathies like retinopathy of prematurity.
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How the placenta affects insulin during pregnancy
This research explores how tiny molecules from the placenta might control how a mother's body uses insulin during pregnancy.
Quick answers
How many clinical trials run by Tufts Medical Center are recruiting right now?
20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.