Veverimer to reduce acid in diet-related bone loss in adults with osteopenia
Official title: Veverimer to decrease net acid excretion and bone resorption in adults with osteopenia: a dose-finding randomized controlled trial
Funded at Tufts Medical Center · NIH-11384241 · Data updated 2026-11-12
A medication called veverimer is being tested in adults with osteopenia to see if it helps reduce bone loss by neutralizing excess acid from the diet without causing extra sodium or potassium problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 10, 2025 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $308,152 |
| NIH project number | 5R61AR085647-02 |
| Project ID | NIH-11384241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older with osteopenia who consume acid-producing diets and are not experiencing prohibitive hypertension or electrolyte issues.
✕Less likely to help
Individuals without osteopenia or those with conditions that would make alkali therapy unsafe or contraindicated may not benefit.
What this research studies
This trial focuses on adults with osteopenia who consume acid-producing diets and may benefit from a therapy that lowers acid load in the body. It uses a dose-finding randomized design to determine how much veverimer is needed to decrease net acid excretion and bone resorption. Participants will receive veverimer or a control in varying doses over the study period, with safety and bone turnover measured to gauge effects. The goal is to identify a tolerable dose that supports bone health while minimizing side effects and blood pressure concerns.
Why it matters
Potential benefit: If successful, participants could experience slower bone loss and a lower risk of fracture due to improved acid-base balance and bone health.
How similar studies have gone: Previous work suggests alkali therapy can reverse adverse bone effects, supporting the rationale for testing veverimer in this population.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Ceglia, Lisa — Tufts Medical Center
- Study coordinator: Ceglia, Lisa
Related research
Other NIH-funded projects on the same topics.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
-
Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
-
Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
-
Shorter antifungal treatment for kids with candidemia
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
-
Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
-
Shorter antifungal course for kids with candidemia
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.