How a specific protein affects heart muscle health and disease
FHOD3 Regulation of Autophagy Pathway in Cardiomyopathy
This study is looking at how a protein called FHOD3 affects heart muscle cells and could help us understand and treat conditions like hypertrophic cardiomyopathy (HCM) by using special techniques to see how a specific gene change impacts heart health and cell repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11175408 on NIH RePORTER |
What this research studies
This research investigates the role of the FHOD3 protein in heart muscle cells and its impact on conditions like hypertrophic cardiomyopathy (HCM). By using advanced techniques such as CRISPR to create a mouse model with a specific genetic variant, researchers will explore how this variant influences heart function and the process of autophagy, which is crucial for cell health. The study aims to understand how stimulating or inhibiting autophagy can affect heart health in the context of this genetic variant, potentially leading to new treatment strategies for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with a diagnosis of hypertrophic cardiomyopathy or those with a family history of heart disease.
Not a fit: Patients without any genetic predisposition to hypertrophic cardiomyopathy or those with unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health and function in patients with hypertrophic cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in understanding the role of autophagy in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Tufts Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Huggins, Gordon S — Tufts Medical Center
- Study coordinator: Huggins, Gordon S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.