Modeling to Prevent and Control Uterine Cancer
Official title: Comparative Modeling for the Prevention and Control of Uterine Cancer
Funded at Tufts Medical Center · NIH-11522504 · Data updated 2026-11-12
A national modeling effort uses computer simulations to inform better prevention, screening, and treatment of uterine cancer for women.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $618,133 |
| NIH project number | 7U01CA265739-06 |
| Project ID | NIH-11522504 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women at risk for or affected by uterine cancer, and policymakers or clinicians who use modeling to shape care strategies.
✕Less likely to help
Patients not involved in care decisions or in populations not represented in the models may experience limited direct benefit.
What this research studies
This project builds shared natural-history models of uterine cancer across three research groups to project how risk factors and population trends shape cancer incidence and outcomes. It will compare screening and prevention strategies, evaluate treatment options including immunotherapy, and assess cost-effectiveness and harms. The aim is to provide clinicians and policymakers with evidence to reduce deaths and new cases, while adapting to changing obesity rates and other risk factors.
Why it matters
Potential benefit: If successful, the models could guide smarter screening, prevention, and treatment decisions to lower uterine cancer deaths.
How similar studies have gone: Past modeling efforts have informed cancer prevention and treatment decisions, but this project expands to include obesity and diverse risk factors.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Wright, Jason — Tufts Medical Center
- Study coordinator: Wright, Jason
Related research
Other NIH-funded projects on the same topics.
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Comparative modeling to guide uterine cancer care
This grant uses computer models to help doctors and patients understand how to make better decisions about uterine cancer care.
-
Using DNA damage drugs to help the immune system fight uterine cancer
This project combines drugs that increase tumor DNA damage with immunotherapy to help people with recurrent microsatellite-stable uterine cancer who haven't responded to current treatments.
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Dual ATR and PI3K-targeted therapy for uterine cancer
This project will try combining two drugs that block ATR and PI3K to better stop uterine cancers, especially tumors with ARID1A changes or other DNA replication stress.
-
WEE1-targeted treatment for uterine serous and p53-mutant uterine cancer
Testing a drug that blocks the WEE1 protein to try to shrink uterine serous cancers and other uterine cancers with p53 mutations.
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Treating uterine (endometrial) cancer by targeting DNA damage and replication stress
This project develops new treatment approaches that exploit DNA repair weaknesses to help women with advanced or recurrent uterine (endometrial) cancer who need additional options.
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Computer models to improve prevention and care for uterine (endometrial) cancer
Researchers are using computer models to compare prevention, screening, and treatment options for women at risk of or living with uterine cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.