Hypoxia and Eye Injury from Mustard Vesicants
Official title: The Impact of Hypoxia on Mustard Vesicant-Induced Eye Injury
Funded at Tufts Medical Center · NIH-11195942 · Data updated 2026-11-12
This grant investigates how low oxygen levels worsen eye injuries caused by mustard chemicals and what can be done to protect vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 30, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,496,120 |
| NIH project number | 1R01EY037652-01 |
| Project ID | NIH-11195942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with ocular exposure to vesicants or related chemical injuries and those contributing tissue samples for study.
✕Less likely to help
Patients without exposure to vesicants or ocular chemical injuries may not directly benefit from this research.
What this research studies
Mustard vesicants can cause severe and long-lasting eye damage. The research will study how hypoxia and HIF signaling contribute to inflammation and abnormal blood vessel growth after exposure, using both human eye tissues and animal models. Researchers will measure oxygen levels in the eye and map the cellular signaling pathways that respond to low oxygen, then test potential downstream effects with cellular approaches. The work aims to uncover mechanisms that could lead to targeted therapies to prevent vision loss after exposure.
Why it matters
Potential benefit: If successful, the findings could guide new treatments to reduce inflammation and scarring after mustard eye exposure and help preserve sight.
How similar studies have gone: Previous work has linked hypoxia and HIF signaling to various tissue injuries, but the specific role in mustard-induced eye injury is not yet clear, making this a novel area.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Yin, Jia — Tufts Medical Center
- Study coordinator: Yin, Jia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.