Role of blood vessel genes in vascular health and disease
Official title: The Role of Vascular MR-Regulated Genes in Vascular Function and Disease
Funded at Tufts Medical Center · NIH-11356626 · Data updated 2026-11-12
This NIH grant supports building a patient-focused resource and lab models from people with peripheral artery disease to study how blood vessel genes affect blood flow and risk of amputation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2009 |
| Project end | January 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $852,578 |
| NIH project number | 2R01HL095590-14 |
| Project ID | NIH-11356626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are adults with lower-limb PAD undergoing amputation or other vascular procedures, and non-PAD individuals providing control tissues.
✕Less likely to help
Patients without access to tissue donation opportunities or those not undergoing limb procedures may not benefit directly.
What this research studies
The project plans to collect vascular tissue and create cell lines from people with lower-limb PAD and from non-PAD controls to understand how specific genes drive disease. Researchers will develop a biobank of human IP-PAD vessels and primary smooth muscle and endothelial cells to study disease mechanisms. They aim to explore the role of the aldosterone-activated mineralocorticoid receptor in PAD progression and amputation risk. The work focuses on translating observations from human tissue into insights that could guide new treatments for PAD.
Why it matters
Potential benefit: If successful, the findings could inform new therapies to prevent limb-threatening ischemia and amputations in PAD patients.
How similar studies have gone: Previous work with human PAD tissues suggests distinct disease biology; this project builds a larger, specialized biobank to strengthen translational insights.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Jaffe, Iris Z — Tufts Medical Center
- Study coordinator: Jaffe, Iris Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.