Pulmonary embolism with right-to-left heart or lung shunts

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study enrolling adults with acute pulmonary embolism to determine whether a concurrent right-to-left shunt (RLS) increases the short-term risk of stroke. Participants will be characterized for RLS (for example PFO, ASD, or pulmonary AVM) using appropriate imaging and clinical tests and then followed for stroke outcomes. The study compares stroke rates between PE patients with and without an identified RLS without altering standard clinical care. Data collection occurs at Tufts Medical Center with collaborators contributing device/diagnostic expertise.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18
2. Acute pulmonary embolism (any grade/size)
3. Patient or legally authorized representative is able to provide consent to participate in the study

Exclusion Criteria:

1. Patients who, in the opinion of the study investigators, are unable to participate in required study activities
2. Patients unable to undergo MRI imaging

Where it's running

• Tufts Medical Center
  Boston, Massachusetts, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.