Comparative modeling to guide uterine cancer care
Official title: Comparative Modeling of Uterine Cancer
Funded at Tufts Medical Center · NIH-11495550 · Data updated 2026-11-12
This grant uses computer models to help doctors and patients understand how to make better decisions about uterine cancer care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 17, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,270,995 |
| NIH project number | 1U01CA319216-01 |
| Project ID | NIH-11495550 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with uterine cancer or at risk of it, and clinicians involved in treatment planning, especially those considering fertility preservation and molecularly guided therapies.
✕Less likely to help
Patients seeking immediate, non-model-based clinical interventions may not directly benefit from this modeling work.
What this research studies
Researchers will use population-level mathematical models to simulate real-world outcomes for different uterine cancer care paths. The goal is to clarify how screening, diagnosis, treatment choices, and fertility considerations affect survival and quality of life. The work translates complex data into insights that could inform personalized treatment and policy decisions for patients and clinicians. It focuses on improving access to care and precision treatment in a disease with rising mortality.
Why it matters
Potential benefit: If successful, the work could lead to better, more individualized care decisions for women with uterine cancer and help policymakers prioritize effective strategies.
How similar studies have gone: Previous CISNET models have shown value in guiding cancer control decisions, with ongoing refinements improving realism and usefulness.
Where this research is happening
-
Tufts Medical Center
Boston, United States Active
Researchers
- Principal investigator: Wright, Jason — Tufts Medical Center
- Study coordinator: Wright, Jason
Related research
Other NIH-funded projects on the same topics.
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Modeling to Prevent and Control Uterine Cancer
A national modeling effort uses computer simulations to inform better prevention, screening, and treatment of uterine cancer for women.
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Using DNA damage drugs to help the immune system fight uterine cancer
This project combines drugs that increase tumor DNA damage with immunotherapy to help people with recurrent microsatellite-stable uterine cancer who haven't responded to current treatments.
-
Dual ATR and PI3K-targeted therapy for uterine cancer
This project will try combining two drugs that block ATR and PI3K to better stop uterine cancers, especially tumors with ARID1A changes or other DNA replication stress.
-
WEE1-targeted treatment for uterine serous and p53-mutant uterine cancer
Testing a drug that blocks the WEE1 protein to try to shrink uterine serous cancers and other uterine cancers with p53 mutations.
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Treating uterine (endometrial) cancer by targeting DNA damage and replication stress
This project develops new treatment approaches that exploit DNA repair weaknesses to help women with advanced or recurrent uterine (endometrial) cancer who need additional options.
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Computer models to improve prevention and care for uterine (endometrial) cancer
Researchers are using computer models to compare prevention, screening, and treatment options for women at risk of or living with uterine cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.