Sponsor or institution
Clinical trials and research at Temple Univ of the Commonwealth
As of November 12, 2026, Find a Trial lists 315 NIH-funded research projects at this institution, with $139.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 315NIH research projects
NIH-funded research (newest 40 of 315)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Complement in the heart’s microenvironment during renewal
This grant explores how immune signals involving the Complement system help heart cells multiply to repair the heart after a heart attack, with the goal of helping patients recover better.
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Integrating clinical pharmacists into HIV care to reduce cardiovascular disease in people with HIV
A pharmacist-led program in HIV care aims to prevent and manage heart disease risks like high blood pressure, diabetes, and high cholesterol in people living with HIV.
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NMDAR-TRPM4 signaling and mitochondria in Alzheimer's disease
Scientists are studying how a specific brain cell signaling pathway (NMDAR-TRPM4) relates to nerve cell damage and memory loss in Alzheimer's disease, using patient-derived stem cell models.
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Understanding how human chaperone networks affect Alzheimer’s- and dementia-related proteins in yeast
Aims to map how human helper proteins (chaperones) interact with dementia-linked proteins using yeast to find which combinations could prevent harmful protein clumps.
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CRISPR-based Cure for HIV: Targeting reservoirs and boosting immunity
Aims to use CRISPR gene editing to directly cut HIV provirus and strengthen immune responses so people living with HIV can better control the virus even after stopping therapy.
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Steric-free labeling to map disease-related protein modifications
A scientist-led study uses advanced labeling tricks to identify disease-related protein modifications in human cells.
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Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
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Role of bacterial biofilms in triggering anti-DNA antibodies in lupus
This research explores how gut bacteria and their biofilm components may provoke the antibody responses seen in lupus (SLE) and how certain bacterial factors might influence disease markers.
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Understanding How Episodic Memory Develops in Children and Adults
A science project is studying how children's and adults' episodic memory develops over time and what brain and life factors shape it.
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Molecular controls shaping color-vision circuit connections
Researchers are studying how color-vision neurons in fruit flies connect properly by linking how these cells are formed with how they find their targets.
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Predicting Vibrio infection severity using patient and community data
This grant aims to build a tool that uses personal health factors and local community data to identify people at higher risk of severe Vibrio infections.
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Clothes Laundries and Airborne Plastic Particles: A Community Health Program
This project aims to understand and reduce workers’ exposure to airborne nano- and microplastics in laundry and dry-cleaning settings to protect respiratory health.
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Shared Decision Making for Depression Care in Primary Care
A practical program to help adults with depression in primary care discuss treatment options with their doctors more clearly and together.
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Community outreach to boost breast and colorectal cancer screening and genetic testing in under-resourced communities
A community-focused program aims to raise awareness and participation in breast and colorectal cancer screening and genetic testing among underserved populations.
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Research Education Core at a Cancer Center for training early-career researchers
A program to mentor and develop early-stage investigators and students in cancer research across Temple University and Fox Chase Cancer Center.
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Planning and Evaluation Core for Cancer Center Partnership
A core team uses a structured planning and evaluation framework to track how cancer research and outreach efforts at Temple University Fox Chase Cancer Center and Hunter College affect cancer burden in communities.
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Biostatistics and Bioinformatics Core helps cancer researchers analyze data
A specialized team provides expert statistics, bioinformatics, and computing support to improve cancer research across multiple cities.
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Administrative Core for a regional cancer health partnership
A coordinating hub that strengthens leadership, oversight, and collaboration to accelerate cancer research, training, and outreach across urban and rural communities.
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Cancer health partnership to advance care and research
A joint 10-year program between Temple University/Fox Chase Cancer Center and Hunter College to speed up cancer research and improve care for patients.
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Lysosomal ion imbalances in heart disease
Aims to understand how lysosome-driven calcium and proton leakage worsens heart disease and whether targeting this process could protect heart cells.
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Functional immune profiling in sepsis patients to guide personalized therapies
A patient-focused study will analyze how neutrophils from people with sepsis interact with blood vessels, using advanced tests and computer models to find distinct immune patterns.
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Improve how patients and providers talk about live-donor kidney transplants
A study will look at how conversations during kidney transplant evaluations influence whether people receive a live-donor transplant.
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Blood markers to predict colorectal cancer risk in African Americans
Scientists are studying a blood test that uses DNA methylation patterns to identify people at higher risk for colorectal cancer, with a focus on African American communities.
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Integrating clinical pharmacists in HIV care to cut cardiovascular risk
A pharmacist-led program in HIV care aims to lower blood pressure, diabetes, and cholesterol problems, improving heart health for people living with HIV.
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Preventing repeated child sexual abuse in at-risk children
A researcher team is testing new ways to prevent repeated child sexual abuse by analyzing big data from child welfare and law enforcement to guide better prevention efforts.
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Targeted mRNA therapies to treat ARDS
A scientist is developing a lung-targeted nanoparticle system to deliver therapeutic mRNA directly to lung cells to help people with ARDS.
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Measuring how key metabolic cofactors are organized inside cells
Scientists will study how acyl-CoA molecules are kept in different parts of human cells and what that means for health and disease.
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Factors that shape HBV screening and liver disease care in Asian Americans
This project looks at how individual and clinical factors influence HBV screening and liver disease care for Asian Americans in the Philadelphia-New York area.
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Understanding how ATP control in TB bacteria could lead to better treatments
This grant looks at how the energy factory of the tuberculosis bacteria is controlled and how that knowledge could help make drugs that work even when the bacteria resist current treatments.
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Automated early bone-loss detection in dental X-rays for timely periodontal care
A clinician-facing AI tool helps identify subtle bone loss patterns in dental X-rays that are invisible to the naked eye, aiming to enable earlier diagnosis and prevention of periodontitis in adults.
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Salmonella biofilms and autoimmune arthritis risk in humans
This project explores how a Salmonella infection may trigger autoimmunity and inflammatory joint disease in people who carry certain genetic factors.
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DLK/JNK signaling in distal axons and its role in nerve damage and maintenance
This project explores how a specific protein signaling pathway (DLK/JNK) affects nerve fibers after injury and under disease-like conditions, with the aim of finding new ideas to protect or repair neurons.
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How immune cells and beta blockers affect heart healing after a heart attack
A research program is examining how certain drug targets on immune cells influence heart healing after a heart attack, with hopes of improving outcomes for people who survive acute heart injury.
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Heart signals may influence fat and the body through tiny vesicles
A heart-focused research grant is exploring how heart-derived factors carried in tiny vesicles can affect fat tissue and overall metabolism, especially after a high-fat diet, with potential implications for heart health and weight management.
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How heart cells talk to blood vessels after a heart attack
This project studies how endothelial cells and heart muscle cells communicate after a heart attack to help blood vessels grow back and limit damage.
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Core C: A central hub to advance heart research
A core facility at Temple University helps multiple heart studies share resources and expertise to better understand how exosomes influence heart injury and protection.
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Exosome Production and Analysis Core Supporting Cardiovascular and Aging Research
A core facility helps scientists grow, isolate, and study exosomes from cell cultures and human samples to advance aging and heart disease research.
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Administrative Core supports a multi-project program at Temple University
A central administrative hub coordinates budgets, meetings, communications, and progress across multiple research projects at Temple University.
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Exosomes and heart repair: how tiny messages from damaged heart communicate with your body
This grant asks how tiny particles called exosomes help heart cells talk to each other and to other organs after injury, with the aim of improving heart healing.
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RBPMS: A new RNA regulator that keeps the heart beating well and may help heart disease
A scientist is studying how a protein called RBPMS helps heart cells work properly and how it might protect the heart in disease.
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