Functional immune profiling in sepsis patients to guide personalized therapies
Official title: Functional Immune Phenotyping of Sepsis Patients: Integrating Microphysiological Assays, Omics and In Silico Modeling
Funded at Temple Univ of the Commonwealth · NIH-11403865 · Data updated 2026-11-12
A patient-focused study will analyze how neutrophils from people with sepsis interact with blood vessels, using advanced tests and computer models to find distinct immune patterns.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 5, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $655,280 |
| NIH project number | 5R01HL181042-02 |
| Project ID | NIH-11403865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sepsis or septic shock who consent to participate and provide blood samples for immune profiling.
✕Less likely to help
Patients without neutrophil dysregulation or those unable to participate in blood-based immune profiling may see limited benefit.
What this research studies
This project will collect samples from sepsis patients to study neutrophil behavior, barrier function with the endothelium, and related omics data. Researchers will use microphysiological assays, high-throughput bioassays, and computer modeling to identify neutrophil subtypes and their impact on organ injury. The goal is to map how immune cell differences relate to the severity of sepsis and to point toward targeted treatment strategies. Participation could involve blood draws and health information sharing under strict privacy protections. The insights aim to inform future therapies that more precisely modulate the immune response in sepsis.
Why it matters
Potential benefit: If successful, the work could lead to more personalized therapies for sepsis by targeting specific neutrophil phenotypes.
How similar studies have gone: Previous work shows neutrophil diversity exists in sepsis, with some studies linking phenotypes to outcomes, but comprehensive functional-omics integration is still emerging.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Kilpatrick, Laurie E. — Temple Univ of the Commonwealth
- Study coordinator: Kilpatrick, Laurie E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.