How heart cells talk to blood vessels after a heart attack
Official title: Project 1
Funded at Temple Univ of the Commonwealth · NIH-11387609 · Data updated 2026-11-12
This project studies how endothelial cells and heart muscle cells communicate after a heart attack to help blood vessels grow back and limit damage.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2017 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $388,605 |
| NIH project number | 5P01HL134608-08 |
| Project ID | NIH-11387609 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals who have experienced a recent or prior acute myocardial infarction and are connected with cardiology care at participating sites may be eligible for related future trials or translational studies.
✕Less likely to help
People without a history of heart attack or without access to the involved care settings may not directly benefit from this research.
What this research studies
After a heart attack, the tiny blood vessels in the heart are damaged, and this grant explores how signals from stressed heart cells influence nearby blood vessel cells and bone-marrow derived cells to promote new vessel growth. The researchers focus on extracellular vesicles and other communication signals that may guide angiogenesis and tissue repair in the damaged area. By understanding these cellular conversations, the work aims to identify mechanisms that could improve blood flow and reduce adverse remodeling of the heart. The project uses a P01 framework to integrate these insights across multiple aims in the Temple University system, led by Dr. Raj Kishore.
Why it matters
Potential benefit: If successful, the research could lead to new ways to improve heart repair after a heart attack by promoting healthier blood vessel growth and reducing heart damage.
How similar studies have gone: Previous work has shown that cell communication signals can influence blood vessel growth after heart injury, making this a promising and increasingly supported approach.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Kishore, Raj — Temple Univ of the Commonwealth
- Study coordinator: Kishore, Raj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.