Exosomes and heart repair: how tiny messages from damaged heart communicate with your body
Official title: Exosomes as mediators of cardiac injury and repair
Funded at Temple Univ of the Commonwealth · NIH-11387603 · Data updated 2026-11-12
This grant asks how tiny particles called exosomes help heart cells talk to each other and to other organs after injury, with the aim of improving heart healing.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2017 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,331,634 |
| NIH project number | 5P01HL134608-08 |
| Project ID | NIH-11387603 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have experienced heart injury or are at risk of heart disease may be considered for future interventions stemming from this work.
✕Less likely to help
Healthy individuals without heart disease are unlikely to benefit directly from this study.
What this research studies
The project studies how exosomes released after heart injury affect signaling between heart cells and distant sites like bone marrow and fat tissue. Researchers will use human-relevant models to map which messages are sent, what cells respond, and how these communications influence repair and recovery. The goal is to identify therapeutic targets that could enhance healing and protect heart function after injury. Participants would benefit from clearer pathways to faster and more complete heart recovery if successful.
Why it matters
Potential benefit: If the approach succeeds, patients could experience better heart repair and function after injury.
How similar studies have gone: Prior work suggests exosome signaling plays a key role in heart biology, with promising but early results in translating to therapies.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Kishore, Raj — Temple Univ of the Commonwealth
- Study coordinator: Kishore, Raj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.