Lysosomal ion imbalances in heart disease
Official title: Lysosomal ionic dysregulation in heart disease
Funded at Temple Univ of the Commonwealth · NIH-11406176 · Data updated 2026-11-12
Aims to understand how lysosome-driven calcium and proton leakage worsens heart disease and whether targeting this process could protect heart cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 4, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $703,206 |
| NIH project number | 5R01HL180055-02 |
| Project ID | NIH-11406176 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with or at risk for cardiac diseases where lysosomal dysfunction may play a role, though the grant itself uses preclinical models.
✕Less likely to help
Patients without cardiac disease or those not related to lysosomal pathways may not benefit.
What this research studies
This research investigates how the lysosome’s ion balance affects heart cell survival during stress, focusing on a channel called TPC2. The team will study how TPC2 activity influences calcium transfer, mitochondria health, and cell death in heart muscle cells, using both lab models and animal studies. By testing interventions that modulate lysosomal ion release, the project seeks to identify new ways to preserve heart function after injury. The goal is to translate these findings into strategies that could reduce heart damage in patients with cardiac disease.
Why it matters
Potential benefit: If successful, this work could lead to new targets and therapies to protect the heart from injury and progression of heart disease.
How similar studies have gone: Previous studies have linked lysosomal ion channels to cardiomyocyte death and stress responses, supporting potential impact of this approach.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Simon, Jillian Noelle — Temple Univ of the Commonwealth
- Study coordinator: Simon, Jillian Noelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.