Steric-free labeling to map disease-related protein modifications
Official title: Steric-free labeling strategies to study disease-related non-histone substrates of post-translational modifications
Funded at Temple Univ of the Commonwealth · NIH-11513495 · Data updated 2026-11-12
A scientist-led study uses advanced labeling tricks to identify disease-related protein modifications in human cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2019 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $431,043 |
| NIH project number | 5R35GM133468-07 |
| Project ID | NIH-11513495 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include people with cancer or chronic inflammatory diseases where dysregulated PTMs play a role, for future therapeutic development.
✕Less likely to help
Patients without these specific disease contexts may not directly benefit from this discovery-focused work.
What this research studies
Researchers will use fluorine-based, biorthogonal chemistry to label non-histone proteins that carry disease-related post-translational modifications like acetylation and O-GlcNAc, helping map important protein interactions. The project aims to reveal new protein targets and PPIs involved in cancer and inflammatory diseases, which could guide future therapies. The work combines chemical biology with cellular studies to understand how these modifications influence protein function and disease progression. If successful, this approach may uncover novel intervention points for treating difficult cancers and inflammatory conditions.
Why it matters
Potential benefit: Could lead to new targets for therapies that treat cancer and inflammatory diseases by understanding how disease-related protein modifications control cell behavior.
How similar studies have gone: Prior studies show that mapping non-histone PTMs can reveal disease-relevant protein interactions, suggesting this approach is promising but still exploratory.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Wang, Ross — Temple Univ of the Commonwealth
- Study coordinator: Wang, Ross
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.