RBPMS: A new RNA regulator that keeps the heart beating well and may help heart disease
Official title: RBPMS, a novel RNA splicing regulator of cardiac function and disease
Funded at Temple Univ of the Commonwealth · NIH-11386573 · Data updated 2026-11-12
A scientist is studying how a protein called RBPMS helps heart cells work properly and how it might protect the heart in disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL171888-04 |
| Project ID | NIH-11386573 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with heart disease or heart failure, or those who have treatment-related heart injury, may benefit from future therapies informed by this research.
✕Less likely to help
This research is basic-to-translational and may not directly benefit individuals who do not have heart disease or related conditions.
What this research studies
This project looks at how RNA splicing proteins like RBPMS influence adult heart function and heart failure. It builds on prior work showing RBPMS helps heart cells grow and respond to stress, and now examines its role in keeping heart contraction strong. The research uses human cells derived from pluripotent stem cells and relevant animal models to understand how RBPMS changes heart gene splicing and contractility. The goal is to identify whether boosting RBPMS could improve heart function in people with heart disease. The work aligns with a translational path from basic biology to potential clinical impact while prioritizing careful experimental design and relevance to human heart conditions.
Why it matters
Potential benefit: If successful, this work could lead to new ways to preserve heart function in patients with heart disease by targeting RNA splicing pathways.
How similar studies have gone: Previous findings suggest that manipulating RBPMS can influence heart cell function and survival, supporting potential benefits of this approach.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Gan, Peiheng — Temple Univ of the Commonwealth
- Study coordinator: Gan, Peiheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.