Measuring how key metabolic cofactors are organized inside cells
Official title: Measuring compartmentalized metabolism of cofactors
Funded at Temple Univ of the Commonwealth · NIH-11396312 · Data updated 2026-11-12
Scientists will study how acyl-CoA molecules are kept in different parts of human cells and what that means for health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $277,375 |
| NIH project number | 5R35GM156596-02 |
| Project ID | NIH-11396312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; the study is laboratory-based and uses cellular models to advance knowledge that could inform future human research.
✕Less likely to help
Participants are not involved in this grant.
What this research studies
This grant aims to map where important energy-related molecules (acyl-CoA) are located inside cells, including mitochondria, cytoplasm, and possibly the nucleus, and how these locations affect metabolism and signaling. The research will push the sensitivity of single-cell metabolomics to see these molecules at the smallest scales and test whether their methods work in other metabolites. Funded under a flexible MIRA award, the project seeks bold, exploratory breakthroughs in both technique and biology that could illuminate how metabolism is spatially organized in human cells.
Why it matters
Potential benefit: Understanding cellular metabolism at the subcellular level could lead to new ways to diagnose or treat metabolic disorders by revealing how mislocalized metabolites contribute to disease.
How similar studies have gone: Previous work showed that compartmentalized metabolite pools can be measured and that subcellular metabolism influences signaling and disease pathways.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Snyder, Nathaniel W. — Temple Univ of the Commonwealth
- Study coordinator: Snyder, Nathaniel W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.