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Clinical trials and research at Roswell Park Cancer Institute

• 55Clinical trials
• 2New in 30 days
• 1Country

Newest trials

All recruiting trials (55)

• Optimal defaults grocery shopping to promote healthy diets for pediatric cancer survivors and families

  This trial tests whether making healthy food the automatic choice when shopping (using Instacart) helps pediatric cancer survivors and their families eat better.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07901816

• Chatbot-assisted family history and cancer risk assessment in genetic counseling

  A chatbot program tests whether it can collect medical history and estimate cancer risk for patients starting genetic counseling for hereditary breast cancer and other cancer risks.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07887620

• Hot-spot SBRT vs standard SBRT for early-stage NSCLC

  This trial tests whether adding intentional high-dose hot spots to SBRT improves tumor control in people with early-stage non-small cell lung cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT07718672

• Weight-loss programs to slow kidney cancer progression in small renal masses on active surveillance

  This study tests two weight-loss approaches, daily calorie restriction and 5:2 intermittent fasting, to see if they help people with small kidney tumors on active surveillance lose weight and potentially slow cancer progression.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07714018

• GB-5267 for platinum-resistant ovarian, peritoneal, or fallopian tube cancer

  This early-phase trial test GB-5267 in adults with platinum-resistant ovarian cancer to see if it is safe and can help shrink tumors.

  Recruiting Phase 1 Roswell Park Cancer Institute · Buffalo, New York · NCT07489287

• Tobacco and cannabis co-use: how young adults start, escalate, and maintain dual use

  This project sees how 18–30-year-olds who use cannabis weekly start, escalate, and keep using either daily cigarettes or daily nicotine vapes.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07439471

• Pain patterns and opioid use in adolescent and young adult sarcoma survivors

  This project tests whether a 3-month smartphone-based daily survey can work for adolescents and young adult sarcoma survivors who have ongoing pain or use opioids.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07402577

• Pegcetacoplan with modified FOLFIRINOX for metastatic pancreatic cancer

  This trial tests whether adding pegcetacoplan to modified FOLFIRINOX helps people with metastatic pancreatic ductal adenocarcinoma.

  Recruiting Phase 1/2 Roswell Park Cancer Institute · Buffalo, New York · NCT07214298

• Using line-field confocal OCT to map Mohs surgery margins for basal cell carcinoma

  This tests whether line-field confocal optical coherence tomography (LC-OCT) can noninvasively show the edges of basal cell carcinomas in adults scheduled for Mohs surgery.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07182240

• Carcinogen and toxicant exposure among young adults who co-use e-cigarettes and cannabis

  This project will measure nicotine, cannabis, and toxicant levels in blood and urine and compare use behaviors in 18–25-year-olds who primarily use e-cigarettes, cannabis, or both.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07167225

• How modified-risk claims change the sensory experience of smokeless tobacco

  This test sees whether modified-risk messages on smokeless tobacco products change sensory experiences and future use intentions for adult daily cigarette smokers.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07107139

• How modified-risk claims affect demand for Copenhagen and General Snus

  This project will test whether new 'modified risk' claims for Copenhagen and General Snus change daily smokers' interest in trying them and how much they'd be willing to pay.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT07102082

• GT103 plus pembrolizumab for advanced STK11‑mutant non‑small cell lung cancer

  This trial tests whether adding GT103 to pembrolizumab can help adults with advanced or metastatic STK11‑mutant non‑small cell lung cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT07017829

• Olanzapine to prevent appetite loss during chemoradiation for head and neck cancer

  This trial tests whether adding olanzapine to usual symptom care can help prevent appetite loss and weight loss in adults receiving chemoradiation for head and neck cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06995508

• Cranial electrotherapy plus group life coaching for burnout in oncology healthcare workers

  This project will test whether daily cranial electrotherapy stimulation combined with group life coaching can reduce burnout and moral distress and improve resilience and job retention for patient-facing oncology healthcare workers.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06977503

• Financial Compass intervention for head and neck cancer patients facing financial hardship

  This study is testing a new program called Financial Compass to see if it can help head and neck cancer patients who are struggling with money feel more supported compared to regular care.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06896695

• CD83-targeted CAR T cell therapy for adults with relapsed or refractory acute myeloid leukemia

  This Phase 1 trial tests a personalized CD83-targeted CAR T-cell infusion to try to eliminate leukemia cells in adults whose AML has relapsed or not responded to prior treatment.

  Recruiting Phase 1 Roswell Park Cancer Institute · Buffalo, New York · NCT06871410

• Better Breathing for Early-Stage Lung Cancer Survivors (New York)

  This program tests whether a 12-week home-based breathing exercise routine helps people who had stage I–III lung cancer breathe better, feel less tired, and stay more active.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06869447

• Nemtabrutinib plus pembrolizumab for Richter transformation (DLBCL subtype)

  This phase II trial tests whether combining nemtabrutinib and pembrolizumab can shrink tumors and help people whose chronic lymphocytic leukemia has transformed into diffuse large B‑cell lymphoma (Richter transformation).

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06863402

• Automated physical activity program for cancer patients

  This study is testing whether a personalized exercise program using wearable technology can help cancer patients be more active compared to regular exercise advice.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06855706

• Post-treatment support program to help Black women breast cancer survivors in Western New York transition into survivorship

  This program tries group sessions and one-on-one peer mentoring to help Black women breast cancer survivors in Western New York adjust to life after finishing treatment.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06833255

• Pre-surgery NALIRIFOX for borderline resectable pancreatic ductal adenocarcinoma

  This phase II study tries NALIRIFOX (liposomal irinotecan plus oxaliplatin, 5‑fluorouracil, and leucovorin) before and after surgery to see if it helps people with borderline resectable pancreatic ductal adenocarcinoma.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06821997

• Testing how well smokers can identify cigarette flavors

  This study tests how well daily smokers can recognize different flavors in menthol cigarettes to understand how it affects their smoking habits.

  Recruiting Early Phase 1 Roswell Park Cancer Institute · Buffalo, New York · NCT06816459

• Cruciferous vegetable eating program to reduce recurrence and progression in early-stage bladder cancer

  This trial will test whether a behavioral program that increases cruciferous vegetable intake (like broccoli, cabbage, kale) and a maintenance component can lower recurrence or progression in adults with early-stage non-muscle invasive bladder cancer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06733363

• Testosterone therapy for men with low testosterone and localized prostate cancer on active surveillance

  This study is testing if testosterone therapy can help men with low testosterone and localized prostate cancer feel better and stay safe while they are being monitored for their cancer.

  Recruiting Phase 4 Roswell Park Cancer Institute · Buffalo, New York · NCT06733350

• Community health education to reduce cancer burden in Western New York

  This study is testing a community health education program in Western New York to see if it helps people work together to tackle cancer in their area.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06681077

• Treatment for relapsed or refractory multiple myeloma with extramedullary disease

  This study is testing a new combination of medications to see if it can help people with relapsed or hard-to-treat multiple myeloma that has spread outside the bone marrow.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06627751

• Combining SX-682 with standard treatments for relapsed or refractory multiple myeloma

  This study is testing if adding a new drug called SX-682 to standard treatments can help people with relapsed or refractory multiple myeloma feel better and fight their cancer more effectively.

  Recruiting Phase 1 Roswell Park Cancer Institute · Buffalo, New York · NCT06622005

• Community exercise and nutrition program for cancer survivors

  This study is testing a 12-week exercise and nutrition program to see if it can help cancer survivors feel healthier and improve their quality of life.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06565260

• Stereotactic Ablative Radiotherapy for metastatic cancer treatment

  This study tests if starting stereotactic ablative radiotherapy right away helps people with newly diagnosed metastatic lung, colorectal, or prostate cancer live longer compared to waiting three months to start treatment.

  Recruiting Phase 3 Roswell Park Cancer Institute · Buffalo, New York · NCT06563388

• Tamoxifen plus pegylated liposomal doxorubicin for advanced triple-negative breast cancer

  This trial tests whether combining tamoxifen with pegylated liposomal doxorubicin can shrink or control metastatic or inoperable locally advanced triple-negative breast cancer in patients with low ER expression and a confirmed TP53 genomic alteration who have had prior therapies.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT06434064

• A program to help women navigate breast cancer care

  This study tests a support program designed to help underserved women with breast cancer find the care they need and improve their quality of life.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06350500

• Intervention to improve medication adherence in children with leukemia

  This study is testing a new support program to help families of children with leukemia stick to their medication routine and see if it works better than regular care.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06323044

• Using AI to find biomarkers for better treatment of pancreatic cancer

  This study is trying to find specific markers in blood and tumor samples from pancreatic cancer patients to see if they can help doctors choose the best treatments for future patients.

  Recruiting at 2 sites Roswell Park Cancer Institute · Buffalo, New York and 1 other locations · NCT06320717

• Using fluorescence imaging and light therapy to improve surgery outcomes for advanced colorectal cancer

  This study is testing if using special light to help surgeons see cancer better during surgery, followed by light therapy to kill leftover cancer cells, can improve outcomes for people with advanced colorectal cancer.

  Recruiting Phase 1/2 Roswell Park Cancer Institute · Buffalo, New York · NCT06307548

• Using light therapy after radiation to treat blocked airways from cancer

  This study is testing if a light therapy treatment after radiation can help people with advanced cancer who have blocked airways breathe better and improve their quality of life.

  Recruiting at 2 sites Phase 1/2 Roswell Park Cancer Institute · Buffalo, New York and 1 other locations · NCT06306638

• Community-based exercise program for cancer survivors

  This study tests a 12-week exercise program for cancer survivors to see if it helps them feel better and improves their quality of life.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06206863

• Improving medication adherence in children with leukemia through parenting skills

  This study is testing a new program to help parents of young children with leukemia make sure their kids take their medicine regularly.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT06074666

• Vibration therapy for patients with blood cancers

  This study is testing if a special vibration therapy can help patients with blood cancers improve their bone health and immune response while they receive treatment.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT05893940

• Home-based breathing exercises to reduce side effects in breast cancer treatment

  This study is testing if a 12-week home breathing exercise program can help breast cancer patients feel better by reducing heart and lung side effects from chemotherapy.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT05787834

• Using propranolol with pembrolizumab and chemotherapy for advanced esophageal cancer

  This study is testing whether adding propranolol to the cancer drug pembrolizumab and standard chemotherapy can help people with advanced esophageal cancer live longer and feel better.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT05651594

• Improving quality of life and immune function in multiple myeloma patients through lifestyle changes

  This study is testing whether lifestyle changes like exercise and diet can improve the immune system and quality of life for people with multiple myeloma.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT05312255

• Improving decision-making for early-stage lung cancer patients

  This study is testing whether giving early-stage lung cancer patients a quality of life fact sheet during their treatment decision-making helps them feel better about their choices compared to usual care.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT05292521

• Combining pembrolizumab and bevacizumab with an immune booster for recurrent ovarian cancer

  This study is testing a new combination of two cancer drugs, pembrolizumab and bevacizumab, with or without an immune booster, to see if it helps people with recurrent ovarian cancer feel better and live longer.

  Recruiting at 2 sites Phase 2 Roswell Park Cancer Institute · Buffalo, New York and 1 other locations · NCT05231122

• Combining APL-2 with Pembrolizumab and Bevacizumab for Recurrent Ovarian Cancer

  This study is testing if a new treatment combining APL-2 with pembrolizumab and bevacizumab can help people with recurrent ovarian cancer feel better and live longer compared to just using bevacizumab alone.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT04919629

• Using lamivudine with chemoimmunotherapy for extensive stage small cell lung cancer

  This study is testing if adding lamivudine to standard chemoimmunotherapy can help people with extensive stage small cell lung cancer live longer and stay cancer-free for longer.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT04696575

• Using propranolol with standard treatment for esophageal adenocarcinoma

  This study is testing if adding propranolol to the usual treatment for esophageal adenocarcinoma can make it safer and help patients live longer after surgery.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT04682158

• Investigating biomarkers and clinical features in metastatic breast cancer patients treated with CDK4/6 inhibitors

  This study is trying to learn more about how metastatic breast cancer patients respond to CDK4/6 inhibitors by looking at their medical records and collecting blood and tissue samples to understand the cancer better.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT04526587

• Combining trifluridine/tipiracil with talazoparib for advanced colorectal or gastroesophageal cancer

  This study is testing a new combination of two cancer drugs to see if they can safely help people with advanced colorectal or gastroesophageal cancer.

  Recruiting Phase 1 Roswell Park Cancer Institute · Buffalo, New York · NCT04511039

• Dendritic cell vaccines and pembrolizumab for treating brain metastasis from breast cancer

  This study is testing a new vaccine combined with an immune therapy to see if it can help people with brain metastasis from triple negative or HER2+ breast cancer fight their cancer better.

  Recruiting at 2 sites Phase 2 Roswell Park Cancer Institute · Tampa, Florida and 2 other locations · NCT04348747

• Comparing single-fraction SBRT to standard radiation for metastatic cancer treatment

  This study is testing whether a single session of a special type of radiation therapy can help people with metastatic cancer feel less pain and live longer compared to the usual radiation treatment.

  Recruiting at 3 sites Phase 2 Roswell Park Cancer Institute · Buffalo, New York and 2 other locations · NCT04068649

• Respiratory muscle training before lung cancer surgery

  This study is testing if breathing exercises can help lung cancer patients recover better and avoid complications after surgery.

  Recruiting Phase 2 Roswell Park Cancer Institute · Buffalo, New York · NCT04067830

• Using pulmonary suffusion to control minimal residual disease in sarcoma and colorectal cancer patients

  This study is testing a new way to deliver chemotherapy directly to the lungs in patients with sarcoma or colorectal cancer that has spread there, to see if it helps control the disease better and is safe to use.

  Recruiting Phase 1/2 Roswell Park Cancer Institute · Buffalo, New York · NCT03965234

• Using photoacoustic imaging to examine breast tissue in cancer patients and healthy individuals

  This study is testing a new imaging technique that uses light and sound to see if it can help tell the difference between healthy breast tissue and cancer in women.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT03897270

• Nutrition and exercise interventions for prostate cancer survivors

  This study tests whether personalized nutrition and exercise plans can help prostate cancer survivors feel stronger and healthier while they are receiving hormone therapy.

  Recruiting Roswell Park Cancer Institute · Buffalo, New York · NCT03880422

Quick answers

How many clinical trials run by Roswell Park Cancer Institute are recruiting right now?

55, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 16, Phase 1: 4, Phase 1/2: 4, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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