Respiratory muscle training before lung cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase II trial investigates the effectiveness of respiratory muscle training (RMT) in preventing lung complications after surgery in patients with stage I-IIIB lung cancer. Participants are randomized into two groups: one receiving usual care and the other incorporating RMT exercises using a specialized device. The study aims to assess improvements in respiratory muscle strength, postoperative outcomes, and quality of life, while also exploring molecular markers that may predict patient responses to the training. The trial includes a comprehensive evaluation of health-related quality of life and financial sustainability of the prehabilitation program.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Documented stage I-IIIb lung cancer or is undergoing surgery for diagnosis
* Participant is able to speak, read, and comprehend English
* Participant must be undergoing or is anticipated to either video-assisted thoracic surgery (VATS or robotic surgery) or laparoscopic surgery for curative intent lung resection
* Patients with or without neoadjuvant chemoradiotherapy (CRT) prior to surgery will be included
* Ability to follow written and verbal instructions
* Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure

Exclusion Criteria:

* Documented ischemic heart disease; congestive heart failure or; significant cardiac arrhythmias that would exclude them from having surgery
* Overall medical frailty (clinician discretion) or ECOG \> 2
* Pregnant or nursing female participants
* Unwilling or unable to follow protocol requirements
* Any condition which in the investigator's opinion deems the participant an unsuitable candidate to participate in this study

Where it's running

• Roswell Park Cancer Institute
  Buffalo, New York, United States Recruiting

Study contacts

• Principal investigator: Ellis Levine, MD — Roswell Park Cancer Institute

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.