Carcinogen and toxicant exposure among young adults who co-use e-cigarettes and cannabis
Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)
This project will measure nicotine, cannabis, and toxicant levels in blood and urine and compare use behaviors in 18–25-year-olds who primarily use e-cigarettes, cannabis, or both.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 25 Years |
| Sex | All |
| Sponsor | Roswell Park Cancer Institute Academic / other |
| Locations | 1 site (Buffalo, New York) |
| Trial ID | NCT07167225 on ClinicalTrials.gov |
What this trial studies
This observational project enrolls 18–25-year-olds who are predominant e-cigarette users, predominant cannabis users, or daily co-users and collects self-reported use behaviors alongside biological samples. Blood and urine will be analyzed for nicotine and cannabis metabolites and established toxicants and carcinogen biomarkers while participants complete standardized questionnaires such as the E-cigarette Dependence Scale and the Cannabis Engagement Assessment. The protocol also pilots different recruitment approaches and choices of study completion locations to inform feasibility. The primary aim is to generate effect size estimates needed to calculate sample sizes for a larger follow-up study.
Who should consider this trial
Good fit: Ideal participants are 18–25-year-olds who can read and write English, have no recent kidney disease, and meet one of the use definitions: daily nicotine e-cigarette users, frequent cannabis users (≥3×/week), or daily co-users of both.
Not a fit: People outside the 18–25 age range, those who do not use e-cigarettes or cannabis frequently, or individuals with recent kidney disease or who cannot attend in-person sample collection are unlikely to receive benefit from participation.
Why it matters
Potential benefit: If successful, this work could clarify how co-use affects exposure to nicotine and carcinogens and help guide more targeted prevention or cessation efforts for young adults.
How similar studies have performed: Previous biomarker studies have reliably measured nicotine and cannabis exposure, but few have specifically examined young adult e-cigarette and cannabis co-use, so co-use-specific evidence is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Young adult (18-25 years old). * Ability to read and write in English. * Participants must fall into one of the following groups (based on self-report): * Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month. * Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products. * E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly. * No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit). * Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities. Exclusion Criteria: * Individuals under the age of 18 or over the age of 25. * Currently pregnant or breastfeeding (female participants). * Unwilling or unable to follow protocol requirements
Where this trial is running
Buffalo, New York
- Roswell Park Comprehensive Cancer Center — Buffalo, New York, United States (Recruiting)
Study contacts
- Principal investigator: Danielle Smith, PhD — Roswell Park
- Study coordinator: Ask Rpci
- Email: askroswell@roswellpark.org
- Phone: 1-800-767-9355
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.