Carcinogen and toxicant exposure among young adults who co-use e-cigarettes and cannabis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project enrolls 18–25-year-olds who are predominant e-cigarette users, predominant cannabis users, or daily co-users and collects self-reported use behaviors alongside biological samples. Blood and urine will be analyzed for nicotine and cannabis metabolites and established toxicants and carcinogen biomarkers while participants complete standardized questionnaires such as the E-cigarette Dependence Scale and the Cannabis Engagement Assessment. The protocol also pilots different recruitment approaches and choices of study completion locations to inform feasibility. The primary aim is to generate effect size estimates needed to calculate sample sizes for a larger follow-up study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Young adult (18-25 years old).
* Ability to read and write in English.
* Participants must fall into one of the following groups (based on self-report):
* Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month.
* Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products.
* E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly
* Predominant cigarette consumers: defined as using cigarettes at least daily for the past six months, but not have used other nicotine-containing products more than weekly or cannabis products for the past month
* Predominant cigarette-cannabis co-consumers: defined as those reporting daily cigarette use and use of cannabis at least 3x/week (including smoking or vaping) for at least the past six months, with no more than weekly use of other nicotine-containing products
* No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit).
* Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.

Exclusion Criteria:

* Individuals under the age of 18 or over the age of 25.
* Currently pregnant or breastfeeding (female participants).
* Unwilling or unable to follow protocol requirements

Where it's running

• Roswell Park Comprehensive Cancer Center
  Buffalo, New York, United States Recruiting

Study contacts

• Principal investigator: Danielle Smith, PhD — Roswell Park
• Study coordinator: Ask Rpci
• Email: askroswell@roswellpark.org
• Phone: 1-800-767-9355

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.