Better Breathing for Early-Stage Lung Cancer Survivors (New York)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, home-based intervention comparing moderate/high-intensity respiratory muscle training (RMT) to a low-intensity sham RMT using the PowerLung device, delivered with virtual supervision and unsupervised sessions for 12 weeks. Participants perform 20–30 minute sessions five days per week and provide blood samples at set timepoints; outcomes include symptoms, respiratory and lower-extremity strength, physical activity, and immune markers. The trial's primary aims are feasibility in Black and White lung cancer survivors and effects on symptom management, performance, and markers of anti-tumor immunity and inflammation. Participants are followed for three months after completing the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years of age.
* Able to speak, read and comprehend the English language
* Self-identify as non-Hispanic Black or White.
* Are \< 24 months of histologically confirmed invasive, non-metastatic, lung cancer diagnosis.
* Have received surgical treatment (primarily stage I, II and III) and have completed all cancer treatments (surgery, chemotherapy, radiation).
* Willing to provide biospecimen samples for the study (blood) which will be collected in the comfort of the patient's home by a mobile phlebotomy group.
* Participant must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent form prior to receiving any study related procedure.

Exclusion Criteria:

* Participant has in situ (stage 0) or metastatic (stage IV) disease at study entry.
* Has contraindications for respiratory muscle training (e.g., recent pulmonary embolism, aortic aneurysm, current pneumothorax).
* Unwilling or unable to follow protocol requirements.
* Any condition which in the investigator's opinion deems the participant an unsuitable candidate to participate in the study.

Where it's running

• Roswell Park Cancer Institute
  Buffalo, New York, United States Recruiting

Study contacts

• Principal investigator: Andrew D Ray — Roswell Park Cancer Institute

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.