Using line-field confocal OCT to map Mohs surgery margins for basal cell carcinoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center pilot will use LC-OCT imaging on patients with superficial or mixed-feature basal cell carcinomas who are clinically eligible for Mohs micrographic surgery. Imaging will be performed before surgery using a mineral oil optical interface to capture high-resolution images of tumor margins. Results will be compared with the surgical margin findings from Mohs excision to determine feasibility and potential concordance. The study excludes patients with mineral oil allergy or uncontrolled illnesses that would limit participation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Participant must understand the investigational nature of this study and provide written consent prior to receiving any study-related procedure.
* Participant must be clinically eligible for Mohs surgery as determined by their referring dermatologist and the Mohs surgeon.
* The participant must have a BCC with superficial histology or a BCC with multiple histological features that also include superficial histology, which is appropriate for Mohs surgery.

Exclusion Criteria:

* Known or reported allergy to mineral oil, the optical agent used during imaging.
* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
* . Any condition which in the investigator's opinion deems the subject an unsuitable candidate to undergo imaging procedure.
* Unwilling or unable to follow protocol requirements

Where it's running

• Roswell Park Comprehensive Cancer Center
  Buffalo, New York, United States Recruiting

Study contacts

• Principal investigator: Cerrene Giordano, MD — Roswell Park
• Study coordinator: Ask RPCI
• Email: askrpc@Roswellpark.org
• Phone: 1-800-767-9355

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI-based risk and subtype prediction for basal cell carcinoma using dermoscopic images

  A retrospective study tests an artificial intelligence model to classify basal cell carcinoma as low- or high-risk and to predict histopathological subtypes from archived dermoscopic images.

  Recruiting Istanbul Training and Research Hospital · Istanbul, Istanbul · NCT07677124

• Methionine-Reduced Diet in Solid Tumors (early-phase)

  A small pilot study will test whether a methionine-reduced diet can change blood levels in adults with various solid tumors who are receiving standard cancer therapy.

  Recruiting Early Phase 1 University of California, Irvine · Orange, California · NCT07628634

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• Vitamin D and light therapy to boost skin cancer response before surgery

  This study tests whether giving Vitamin D or a placebo around the time of a light-based treatment (PDT) can help boost skin cancer treatment before Mohs surgery or ED&C in adults with basal cell or squamous cell carcinoma.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07241585

• Neoadjuvant Opdualag (nivolumab + relatlimab) versus nivolumab for resectable high-risk basal cell carcinoma

  This trial tests whether adding relatlimab to nivolumab before surgery helps people with resectable high‑risk basal cell carcinoma shrink tumors and improve surgical outcomes.

  Recruiting at 3 sites Phase 2 University of California, San Diego · Irvine, California and 2 other locations · NCT06624475

• AI-assisted confocal imaging to guide removal of basal cell carcinoma

  This project tests whether an AI tool can analyze confocal microscope images during basal cell carcinoma surgery to give surgeons real-time guidance on which tissue to remove.

  Recruiting LMU Klinikum · Munich, Bavaria · NCT06600165

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.