Testing how well smokers can identify cigarette flavors

Sensory Evaluation of Cigarettes Claiming Removal of Menthol as a Characterizing Flavor

Early Phase 1 Interventional Roswell Park Cancer Institute · NCT06816459

This study tests how well daily smokers can recognize different flavors in menthol cigarettes to understand how it affects their smoking habits.

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Enrollment30 (estimated)
Ages21 Years to 55 Years
SexAll
SponsorRoswell Park Cancer Institute Academic / other
Locations1 site (Buffalo, New York)
Trial IDNCT06816459 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the ability of current daily smokers to identify flavors in menthol cigarettes. It involves a consumer panel of adult smokers who will participate in a series of tests assessing their smell and taste perceptions of various cigarette products. Participants will complete three testing sessions, including the Brief Smell Identification Test and specific smell and taste tests for different cigarette samples. The study aims to gather both quantitative and qualitative data on flavor identification and its implications for smoking behavior.

Who should consider this trial

Good fit: Ideal candidates are adults aged 21-55 who are current daily smokers of factory-made menthol cigarettes.

Not a fit: Patients who do not smoke or who use other tobacco products concurrently may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into how flavoring influences smoking behavior and dependence, potentially informing public health policies.

How similar studies have performed: While studies have explored the effects of menthol on smoking behavior, this specific approach to flavor identification in cigarettes is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged 21-55 years old
* Current daily smoker of factory-made menthol cigarettes
* General good health (assessed by self-rated health item)
* Completion of Brief Smell Identification Test (B-SIT) with no identification of deficits

Exclusion Criteria:

* Daily concurrent use of other tobacco products (e.g., e-cigarettes, cigars, smokeless tobacco)
* Known allergies to mint (peppermint, spearmint), menthol
* Self-reported olfactory or taste deficits
* Pregnant or nursing participants, as indicated by self-report
* History of medications known to interfere with sense of smell
* Positive diagnosis of coronavirus 2019 (COVID-19) within 10 days of enrollment
* Current upper respiratory infection or sinus congestion (e.g., cold, flu, seasonal allergies) (by self report)

Where this trial is running

Buffalo, New York

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Cigarette Smoking-Related Carcinoma
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.