Sponsor or institution
Clinical trials and research at Indiana University Indianapolis
As of November 12, 2026, Find a Trial lists 879 NIH-funded research projects at this institution, with $547.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 879NIH research projects
NIH-funded research (newest 40 of 879)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Adapting flow cytometry to detect childhood leukemias in Kenya using a single-test screen
A low-cost, blood-based flow cytometry screen in Kenya aims to detect and triage suspected leukemias in children and young adults.
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Dementia care staff study: adapting a US survey for use in many countries
A study is adapting and testing a survey for dementia care workers in the US, Brazil, Switzerland, and Ghana to help understand why workers stay in their jobs and how to improve care.
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Dementia care staff study: adapting a survey for use in many countries
A multinational study will adapt and test a U.S. dementia-care worker survey in Brazil, Switzerland, and Ghana to help understand why staff stay in or leave long-term care settings.
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Study of Dementia Care Staff in 4 Countries: Adapting Caregiver Surveys Across Cultures
A multinational project will adapt and test a dementia care worker survey so researchers can compare care environments across the US, Brazil, Switzerland, and Ghana.
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Severe malaria and brain risk in children
This grant studies how severe malaria in young children can affect brain development and long-term thinking and behavior, with a focus on kids in Uganda.
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Tau filament structure in Alzheimer’s and related dementias
Aims to map the detailed 3D shapes of tau protein filaments found in human brain diseases to help develop better diagnostics and treatments for Alzheimer’s-related dementias.
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HIV care and treatment in East Africa: understanding how people stay in care and achieve viral suppression
A regional effort in East Africa uses health data and smart analysis to understand what helps people living with HIV stay in care and maintain viral suppression amid changing global funding.
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East Africa AIDS care and outcomes database: regional insights for treatment and retention
A regional program in East Africa uses health data to understand how people stay in HIV care and keep viral loads low, even as funding and health systems change.
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East Africa HIV care and treatment outcomes study
This project looks at how people living with HIV in East Africa stay in care, adhere to treatment, and achieve viral suppression over time.
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East Africa HIV Care and Treatment Insights Across Regions
A regional collaboration is extending its work to understand how people in East Africa stay in HIV care and achieve viral suppression as funding and programs change.
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East Africa AIDS care: how people living with HIV stay in treatment and reach viral suppression
A kidney-friendly plain-English description of a study in East Africa to learn why people on HIV treatment stay in care or drop out and how to improve long-term viral suppression.
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HIV care and treatment in East Africa: understanding retention and outcomes
This project looks at how people living with HIV in East Africa stay in care and achieve viral suppression, and how patient development and broader health systems affect outcomes.
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Exocrine–Endocrine Crosstalk and Beta Cell Growth in Diabetes
This project explores how pancreatic cells that make insulin grow and regulate themselves, with a focus on type 2 diabetes in adults.
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How bone marrow stem cells find their home
A physician-scientist is pursuing training to understand how bone marrow stem cells interact with their bone marrow environment to improve stem cell transplants in patients.
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Autoimmune diabetes: how beta cells cope with stress and keep them healthy
A study to understand how pancreatic beta cells handle stress and how this affects the risk and progression of type 1 diabetes, with a focus on autophagy and antioxidant responses.
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Hematopoietic stem and progenitor cell regulation to improve therapies
This grant supports a multi-institutional effort to understand how blood-forming stem cells work so that stem cell–based therapies can be safer and more effective for patients.
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Malaria-related kidney injury and its link to chronic kidney disease in children
This grant looks at why some children who have malaria develop kidney injury and later chronic kidney disease, focusing on how severe malaria affects the kidneys over time.
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Whole-chromosome fine-mapping across diverse ancestries to understand psychiatric disorders
A study to pinpoint the exact genetic changes that contribute to bipolar disorder and related conditions by using diverse populations to improve accuracy.
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Aging-Era HIV Care in East Africa: Tracking Retention and Outcomes
A long-running project uses East Africa data to understand how people stay in HIV care and achieve viral suppression as funding and health systems change.
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Biospecimen Exchange for Neurological Disorders (BioSEND)
A national biospecimen and data repository for neurological diseases that helps researchers access high-quality samples and data to study conditions like ALS.
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TDP-43 mislocalization and modifications in neurodegenerative diseases
Researchers will study how TDP-43 protein changes and clumps relate to different brain diseases like Alzheimer's and ALS to better understand why symptoms vary.
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How Retinoic Acid Shapes Teeth Development in Vertebrates and Why It Matters for People
Researchers are studying how a vitamin A-related signal (retinoic acid) shapes how teeth form in fish to better understand common tooth problems in people.
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Autism outcomes and neurobehavioral markers in HIV-exposed but uninfected children in Kenya
This project follows young children who were exposed to HIV but not infected to understand autism risk and find simple, scalable ways to detect it early.
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Long-term inflammation and immune health in people born with HIV
This study follows children born with HIV as they grow into adulthood to understand how chronic inflammation affects their health over many years.
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MMP9 and brain imaging changes linked to amyloid therapies for Alzheimer's
This grant looks at how a protein called MMP9 may cause brain imaging changes in people treated with anti-amyloid therapies for Alzheimer’s disease.
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Brain effects of severe malaria in children
This project looks at how severe malaria affects children's brains and later development after cerebral malaria or severe malarial anemia.
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Autophagy links to Type 1 Diabetes onset and progression
This project looks at how a cellular recycling process in insulin-producing cells might influence the development and course of Type 1 diabetes in people.
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PERIOx: How body fats and immune signals affect dental implant biofilms
A small study will look at how substances released by the body’s fats and immune cells influence dental implant biofilms in people with peri-implant disease.
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Personalized prognosis for Alzheimer’s and related dementias using brain networks and pathology
A patient-centered computer approach will forecast how Alzheimer's and related dementias may progress by using each person’s brain connections and imaging data over time.
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Post-Tuberculosis Lung Health in Youth with/without HIV
A study in teens and young adults with TB, with or without HIV, to find how common lung problems after TB are and what can be done to prevent them.
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Post-TB lung disease in youth with HIV: global insights
We’re studying how common long-lasting lung problems are in teens and young adults who had TB, including those living with HIV, to find ways to prevent and improve their lung health.
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Post-TB Lung Disease in Teens and Young Adults with HIV globally
This grant studies how common post-tuberculosis lung problems are in youths aged 15–24, including those with HIV, and aims to find factors we can change to keep their lungs healthy.
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How fat, nerves, and blood “chips” could drive AML growth
This NIH grant looks at how obesity-related signals in the body might fuel the growth of certain blood cancer cells in people with or at risk for acute myeloid leukemia.
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IL-9 Signaling and Immune-Driven Preterm Birth
This NIH grant supports training a physician-scientist to lead a new lab studying how immune signals, especially IL-9, affect preterm birth.
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Medicare Advantage and Transplant Access for Rural and Vulnerable Communities
Aimed at understanding how Medicare Advantage affects early steps to kidney transplant for adults in rural or socioeconomically challenged groups.
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Prenatal alcohol exposure may raise risk for postnatal addiction
This grant looks at how drinking during pregnancy could make someone more likely to develop addiction later and what brain signals drive that risk, with a focus on the brain’s reward system.
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Optimizing Emergency Care for Cirrhosis (OCEAN) in the ED
A research team at Indiana University Indianapolis is studying how to make emergency care for people with cirrhosis safer, faster, and more effective.
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Role of CPT1 activation in spinal cord injury
This grant looks at how activating CPT1, a key enzyme in fat metabolism, may influence recovery after spinal cord injury in adults.
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Restoring helper CD4 T cells to help control chronic viral infections
A research project tests a strategy to revive CD4 Th1 helper T cells to better control chronic viral infections like HIV and hepatitis B/C in people who need improved immune control.
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Targeting a transcription factor to control vitamin D–related mineral balance
A research project will study how a specific gene regulator affects how the body makes and uses vitamin D to keep minerals like calcium and phosphate in balance.
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