Targeting a transcription factor to control vitamin D–related mineral balance
Official title: Targeting ETV1 as a Direct Regulator of FGF23-mediated Endocrine 1,25D
Funded at Indiana University Indianapolis · NIH-11448376 · Data updated 2026-11-12
A research project will study how a specific gene regulator affects how the body makes and uses vitamin D to keep minerals like calcium and phosphate in balance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 15, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $789,994 |
| NIH project number | 1R01DK145751-01A1 |
| Project ID | NIH-11448376 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with disorders of vitamin D metabolism or mineral balance may benefit from future therapies developed from these findings.
✕Less likely to help
No immediate benefit for participants in this basic research project, as it does not involve patient testing.
What this research studies
This project focuses on understanding which genetic factors control the final steps of vitamin D production in the kidney and how they respond to signals like PTH and FGF23. Researchers will examine transcription factors that influence enzymes responsible for vitamin D activation and breakdown, using genetic approaches to map their roles. The goal is to connect molecular mechanisms to how vitamin D balance affects mineral diseases in people. The work is designed to generate insights that could inform future therapies for conditions involving abnormal vitamin D metabolism.
Why it matters
Potential benefit: If successful, the findings could lead to new targets for treating mineral disorders related to vitamin D metabolism.
How similar studies have gone: Previous research has shown that transcription factors regulate vitamin D–related enzymes, but the exact mechanisms in humans remain incompletely understood.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: White, Kenneth E — Indiana University Indianapolis
- Study coordinator: White, Kenneth E
Related research
Other NIH-funded projects on the same topics.
-
Adapting flow cytometry to detect childhood leukemias in Kenya using a single-test screen
A low-cost, blood-based flow cytometry screen in Kenya aims to detect and triage suspected leukemias in children and young adults.
-
Dementia care staff study: adapting a US survey for use in many countries
A study is adapting and testing a survey for dementia care workers in the US, Brazil, Switzerland, and Ghana to help understand why workers stay in their jobs and how to improve care.
-
Dementia care staff study: adapting a survey for use in many countries
A multinational study will adapt and test a U.S. dementia-care worker survey in Brazil, Switzerland, and Ghana to help understand why staff stay in or leave long-term care settings.
-
Study of Dementia Care Staff in 4 Countries: Adapting Caregiver Surveys Across Cultures
A multinational project will adapt and test a dementia care worker survey so researchers can compare care environments across the US, Brazil, Switzerland, and Ghana.
-
Severe malaria and brain risk in children
This grant studies how severe malaria in young children can affect brain development and long-term thinking and behavior, with a focus on kids in Uganda.
-
Tau filament structure in Alzheimer’s and related dementias
Aims to map the detailed 3D shapes of tau protein filaments found in human brain diseases to help develop better diagnostics and treatments for Alzheimer’s-related dementias.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.