Post-TB lung disease in youth with HIV: global insights
Official title: Post-Tuberculosis Lung Disease in Youth with and without HIV Globally
Funded at Indiana University Indianapolis · NIH-11454817 · Data updated 2026-11-12
We’re studying how common long-lasting lung problems are in teens and young adults who had TB, including those living with HIV, to find ways to prevent and improve their lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 22, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $108,492 |
| NIH project number | 3R01AI184174-02S2 |
| Project ID | NIH-11454817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals aged 15–24 who have had TB treatment, with or without HIV, and are engaged in care at participating TB clinics.
✕Less likely to help
Some youths may not have measurable PTLD or may not benefit from specific interventions tested in this study.
What this research studies
This project partners with youth-focused TB clinics around the world to measure how many 15–24 year-olds have lingering lung issues after TB treatment. Researchers will collect health data, lung function, mental health, substance use, and social factors over a year after TB treatment begins, to understand what drives PTLD and how it affects quality of life. Using the TB-Sentinel Research Network, the study will enroll about 2,600 participants across 11 countries, with sites in Africa enhancing youth-focused care. The aim is to identify modifiable risk factors and test care models that can be tailored for youth, including those with HIV. The ultimate goal is to guide practical interventions and improve lifelong lung health for these young people.
Why it matters
Potential benefit: If successful, this work could lead to targeted interventions that prevent PTLD and improve lung health and life quality for youth affected by TB and HIV.
How similar studies have gone: Previous studies have shown PTLD is a real issue in adults; data in youth and those with HIV are limited, making this largely exploratory but promising.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Enane, Leslie Anne — Indiana University Indianapolis
- Study coordinator: Enane, Leslie Anne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.