Post-TB Lung Disease in Teens and Young Adults with HIV globally
Official title: Post-Tuberculosis Lung Disease in Youth with and without HIV Globally
Funded at Indiana University Indianapolis · NIH-11454815 · Data updated 2026-11-12
This grant studies how common post-tuberculosis lung problems are in youths aged 15–24, including those with HIV, and aims to find factors we can change to keep their lungs healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 22, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $166,717 |
| NIH project number | 3R01AI184174-02S1 |
| Project ID | NIH-11454815 on NIH RePORTER |
Who could benefit from this research
✓Could help
Teens and young adults aged 15–24 who have pulmonary TB, with or without HIV, enrolled through TB-SRN sites.
✕Less likely to help
Individuals without TB or TB-related lung disease are unlikely to benefit directly.
What this research studies
The project will use data from the TB-Sentinel Research Network to measure how many young people with pulmonary TB develop lung issues after treatment. Researchers will look at personal, medical, and environmental factors that could be changed to prevent PTLD and improve quality of life. Assessments will cover health, adherence to treatment, lung function, mental health, substance use, and social determinants across 11 countries. The work will build on current sites in Africa to test tailored care models that can be scaled to benefit youth living with TB and HIV. The study will follow participants from TB treatment initiation through 12 months after completion to understand long-term outcomes.
Why it matters
Potential benefit: If successful, the findings could guide youth-focused TB care models that prevent PTLD and improve lung health and quality of life.
How similar studies have gone: Prior research suggests PTLD is a real issue; this project builds on existing networks to quantify and address it in youth, which is relatively novel.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Enane, Leslie Anne — Indiana University Indianapolis
- Study coordinator: Enane, Leslie Anne
Related research
Other NIH-funded projects on the same topics.
-
Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
-
Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
-
Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
-
Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
-
Air pollution and TB transmission in Kampala’s urban slums
This project looks at whether air pollution from PM2.5 makes tuberculosis spread more easily from infected people to their neighbors in urban slums of Kampala, Uganda.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.