Personalized prognosis for Alzheimer’s and related dementias using brain networks and pathology
Official title: Personalized Medicine under the Co-evolution of Connectomes and Pathological Proteins
Funded at Indiana University Indianapolis · NIH-11455979 · Data updated 2026-11-12
A patient-centered computer approach will forecast how Alzheimer's and related dementias may progress by using each person’s brain connections and imaging data over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 1, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $791,039 |
| NIH project number | 1R01AG095242-01A1 |
| Project ID | NIH-11455979 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with Alzheimer’s disease or related dementias who have longitudinal brain imaging and cognitive performance data.
✕Less likely to help
Patients whose disease progresses rapidly or whose data do not fit existing patterns may see limited benefit.
What this research studies
This project creates models that combine a person’s cognitive strengths with their brain network maps and disease markers from PET and MRI to predict how ADRD might unfold. It builds on a prior framework to describe individual differences in disease progression and to identify molecular signals that influence brain cell pathways. The goal is to stratify patients into progression subtypes so treatments can be targeted more precisely. The work will include developing new software tools and validating the models in diverse patient data.
Why it matters
Potential benefit: If successful, patients could receive more accurate forecasts of their disease course and more personalized treatment plans.
How similar studies have gone: Previous work shows promise in using brain networks and biomarkers to predict ADRD progression, but patient-centered prognostic profiling remains challenging and needs further validation.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Wang, Selena — Indiana University Indianapolis
- Study coordinator: Wang, Selena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.