Post-Tuberculosis Lung Health in Youth with/without HIV
Official title: Post-Tuberculosis Lung Disease in Youth with and without HIV Globally
Funded at Indiana University Indianapolis · NIH-11454820 · Data updated 2026-11-12
A study in teens and young adults with TB, with or without HIV, to find how common lung problems after TB are and what can be done to prevent them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 22, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $60,295 |
| NIH project number | 3R01AI184174-02S3 |
| Project ID | NIH-11454820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Youth aged 15–24 with pulmonary TB, with or without HIV, especially those in participating TB-SRN sites in Africa.
✕Less likely to help
Youth outside the TB-SRN network or those not currently managed under TB care may see limited direct benefit.
What this research studies
This project will measure how common post-tuberculosis lung disease is among people aged 15–24 across 11 countries and identify modifiable risk factors that affect lung health and quality of life. It partners with the TB-SRN network and follows participants from TB treatment start to one year after completion, collecting data on clinical status, adherence, mental health, and social factors. The study will adapt and strengthen youth-focused TB care at seven sites to address care engagement barriers and social determinants impacting outcomes. By identifying targeted interventions and new care models, the work aims to improve long-term lung health for youth affected by TB and HIV. Enrollment targets 2,600 participants to generate robust, global insights.
Why it matters
Potential benefit: If successful, the project could lead to better prevention and management of PTLD in youth, improving lung health and overall well-being.
How similar studies have gone: Previous work in TB cohorts has shown PTLD is a real concern; this study expands understanding in youth and across multiple countries.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Enane, Leslie Anne — Indiana University Indianapolis
- Study coordinator: Enane, Leslie Anne
Related research
Other NIH-funded projects on the same topics.
-
Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
-
Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
-
Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
-
Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
-
Air pollution and TB transmission in Kampala’s urban slums
This project looks at whether air pollution from PM2.5 makes tuberculosis spread more easily from infected people to their neighbors in urban slums of Kampala, Uganda.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.