Long-term inflammation and immune health in people born with HIV
Official title: Long-term clinical and immunologic consequences of inflammation in perinatal HIV
Funded at Indiana University Indianapolis · NIH-11474045 · Data updated 2026-11-12
This study follows children born with HIV as they grow into adulthood to understand how chronic inflammation affects their health over many years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 7, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $63,167 |
| NIH project number | 3R01HD113487-03S1 |
| Project ID | NIH-11474045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals born with HIV who received ART from early life and have maintained viral suppression, plus HIV-unexposed individuals for comparison.
✕Less likely to help
Individuals not on ART or without long-term follow-up data may not directly benefit from this study.
What this research studies
Researchers will use an existing Kenyan cohort of people born with perinatal HIV who are on long-term antiretroviral therapy to track immune activation, inflammation, and related health outcomes over about 10 years. They will compare people living with perinatal HIV on ART with people who were unexposed to HIV to see how sustained inflammation relates to immune health, cardiovascular risk, metabolism, and neurocognitive function. Data will include immune markers, cardiovascular and metabolic assessments, and neurocognitive testing to paint a global picture of long-term health. The goal is to learn whether viral suppression and prolonged ART reduce inflammation and what the lasting effects might be on development and aging.
Why it matters
Potential benefit: If successful, findings could guide strategies to reduce long-term inflammation and improve health outcomes for people born with HIV.
How similar studies have gone: Previous cross-sectional work suggests persistent inflammation despite ART, and this study extends that to a 10-year follow-up to better understand long-term effects.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Khaitan, Alka — Indiana University Indianapolis
- Study coordinator: Khaitan, Alka
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.