Hematopoietic stem and progenitor cell regulation to improve therapies
Official title: Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy
Funded at Indiana University Indianapolis · NIH-11530327 · Data updated 2026-11-12
This grant supports a multi-institutional effort to understand how blood-forming stem cells work so that stem cell–based therapies can be safer and more effective for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 1, 2015 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $700,000 |
| NIH project number | 5U54DK106846-11 |
| Project ID | NIH-11530327 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with bone marrow diseases who may benefit from improved stem cell therapies or transplantation.
✕Less likely to help
Patients not eligible for stem cell therapies or whose condition does not involve hematopoietic stem cells may see limited direct benefit.
What this research studies
Researchers in this program are studying human and mouse blood-forming stem and progenitor cells to learn what controls their growth, movement, and engraftment. The work involves collaborations across laboratories and cores that handle experiments, data, and potential clinical translation. The goal is to translate basic discoveries about hematopoietic cells into improved therapies that rely on stem cells, with an eye toward future clinical trials.
Why it matters
Potential benefit: If successful, the research could lead to more effective and safer stem cell therapies for blood and bone marrow diseases.
How similar studies have gone: Previous work in hematopoietic stem cell biology has shown progress in understanding engraftment and signaling, supporting the potential of translational advances.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Kapur, Reuben — Indiana University Indianapolis
- Study coordinator: Kapur, Reuben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.