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Clinical trials and research at European Institute of Oncology

• 58Clinical trials
• 1New in 30 days
• 6Countries

Newest trials

All recruiting trials (58)

• Understanding what patients want from NSCLC treatment monitoring

  Researchers are testing how patients with non-small cell lung cancer feel about and prefer monitoring their symptoms during treatment, with input from patients, caregivers, and clinicians.

  Recruiting European Institute of Oncology · Milan, mI · NCT07909343

• Single-Port Robotic Lobectomy for Early-Stage NSCLC

  This study tests the safety and outcomes of using the da Vinci Single-Port system for lobectomy and lymph node dissection in people with early-stage non-small cell lung cancer.

  Recruiting European Institute of Oncology · Milan, Mi · NCT07790406

• Disparities in Mental Health Screening and Support for Cancer Patients and Families

  This study tests whether cancer patients and their families across Europe have equal access to mental health screening and support services.

  Recruiting European Institute of Oncology · Milan, Mi · NCT07691281

• Melanoma Brain Metastases Treated with Stereotactic Radiosurgery and Systemic Therapy

  This study looks at how stereotactic radiosurgery for melanoma brain metastases works when patients are also receiving immunotherapy or targeted therapy.

  Recruiting at 2 sites European Institute of Oncology · Milan, Italy and 1 other locations · NCT07691255

• Predictive biomarkers for immunotherapy in endometrial cancer

  This study tests molecular and epigenetic features to see if they can predict which endometrial cancer patients will respond to immune checkpoint inhibitors.

  Recruiting European Institute of Oncology · Milan, Italy · NCT07690540

• See if Italian patients with cancer experience MRI anxiety and how a translated questionnaire works

  This study tests whether an Italian version of an MRI anxiety questionnaire reliably measures anxiety in adults with cancer undergoing whole-body MRI.

  Recruiting European Institute of Oncology · Milan, Mi · NCT07671846

• Diet quality and nutrient adequacy in vegetarian and vegan women at a Milan cancer institute

  This study tests whether 3 months of personalized vegetarian-focused nutrition counselling improves body composition, activity, and quality of life in vegan, vegetarian, and semi-vegetarian women aged 18–64 attending care at the European Institute of Oncology.

  Recruiting European Institute of Oncology · Milan · NCT07638839

• Endoscopic nipple-sparing mastectomy with video guidance

  This study tests a minimally invasive nipple-sparing mastectomy using endoscopic video guidance to see if it is feasible and safe for appropriately selected breast cancer patients and prophylactic risk carriers.

  Recruiting European Institute of Oncology · Milan · NCT07579117

• Immune changes that may stop laryngeal dysplasia from becoming cancer

  This project will see if immune cells and gene activity in adults with laryngeal dysplasia can predict which lesions will turn into cancer.

  Recruiting European Institute of Oncology · Milan, MI · NCT07508319

• Comparison of thymic, lung, and pancreatic well‑differentiated high‑grade neuroendocrine tumors

  This project will try to see if patients with advanced thymic, lung, or pancreatic well‑differentiated high‑grade neuroendocrine tumors (Ki‑67 >20%) are diagnosed and treated the same and whether tumor genetic changes relate to outcomes.

  Recruiting European Institute of Oncology · Milan, Italy · NCT07429851

• Zolbetuximab with chemotherapy for HER2-negative, Claudin 18.2–positive metastatic gastric or gastroesophageal junction adenocarcinoma

  This project will try zolbetuximab together with FOLFOX or XELOX as first-line treatment for adults whose HER2-negative stomach or gastroesophageal junction cancers strongly express Claudin 18.2.

  Recruiting European Institute of Oncology · Milan · NCT07427992

• Germline TP53 gene testing in patients seen at the IEO

  This project looks at past genetic test results to see how often harmful TP53 changes were found in people who had counseling and germline TP53 testing at the IEO between 2004 and 2025.

  Recruiting European Institute of Oncology · Milan · NCT07419893

• Digital tools to support cancer patients, caregivers, and oncology professionals

  This project will test the Althea digital platform with cancer patients, survivors, caregivers, family members, and oncology professionals to see how well it supports care and psychosocial needs.

  Recruiting European Institute of Oncology · Caen and 4 other locations · NCT07416513

• Elacestrant and Exemestane for HR+/HER2- Breast Cancer with FES-PET Positive Lesions

  This study tests a combination of elacestrant and exemestane in adults with pretreated HR+/HER2- metastatic breast cancer who show FES-PET uptake on scans.

  Recruiting Phase 2 European Institute of Oncology · Milan, Italy · NCT07395336

• Molecular profiling of primary lung cancer and its metastatic site

  This project will compare the DNA of a person’s primary non-small cell lung tumor and a matching metastatic lesion using next-generation sequencing to see if they differ.

  Recruiting European Institute of Oncology · Milan · NCT07325864

• Targeted removal of a marked lymph node for early hormone-receptor positive breast cancer with limited node spread

  This trial tests whether removing the pre-marked suspicious lymph node along with the sentinel lymph node during initial surgery lets people with early ER+/PR+ HER2‑ breast cancer and 1–2 suspicious nodes avoid a full axillary lymph node dissection.

  Recruiting at 5 sites European Institute of Oncology · Bologna, Italy and 13 other locations · NCT07278726

• Sexual well-being after mastectomy and immediate reconstruction

  We will collect short electronic questionnaires from women having mastectomy with immediate reconstruction to see how the surgery affects sexual well‑being.

  Recruiting European Institute of Oncology · Bari, Italy and 18 other locations · NCT07234461

• Breast cancer relapse after adjuvant CDK4/6 inhibitor therapy

  This project will look at people with HR+/HER2- early breast cancer who received adjuvant ribociclib or abemaciclib plus endocrine therapy to see what their tumor features and outcomes are, including those who relapse during or within 12 months after treatment.

  Recruiting at 11 sites European Institute of Oncology · Bergamo, Italy and 17 other locations · NCT07180693

• Sentinel lymph node biopsy after neoadjuvant chemotherapy for inflammatory breast cancer

  This trial will test whether sentinel lymph node biopsy after preoperative chemotherapy is feasible and safe for people with inflammatory breast cancer who initially had extensive lymph node involvement.

  Recruiting European Institute of Oncology · Milan · NCT07080944

• Toxicity markers for Trastuzumab‑Deruxtecan in advanced breast cancer

  This project will test whether blood markers can predict serious side effects, including interstitial lung disease, in adults with metastatic HER2‑positive or HER2‑low breast cancer who are treated with Trastuzumab‑Deruxtecan.

  Recruiting European Institute of Oncology · Milan · NCT07049133

• Personalized external beam radiation for localised breast and prostate tumours

  This project will test whether using optimized MRI scans plus lab-grown tumor samples can help personalize external beam radiation for adults with localized breast or prostate cancer.

  Recruiting European Institute of Oncology · Milan, Italy · NCT07047495

• Emotional distress and first-line treatment outcomes in metastatic breast cancer

  This study will see if emotional distress at the start of treatment changes how well first-line therapies work for people with metastatic breast cancer.

  Recruiting at 8 sites European Institute of Oncology · Ancona and 36 other locations · NCT06994377

• Using 68Ga-FAPi-46 PET/CT to study breast cancer

  This study is testing a new imaging method using a special agent to see if it can help women with node-positive breast cancer get better information about their tumors before starting treatment.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06790264

• Genetic analysis in women with metastatic ovarian cancer during PARP inhibitor treatment

  This study is testing how PARP inhibitor treatment affects the genes and blood cells of women with metastatic ovarian cancer to see if it leads to any serious side effects.

  Recruiting European Institute of Oncology · Milan · NCT06785077

• Understanding lactose intolerance through an online survey

  This study is trying to see how much people in Italy know about lactose intolerance and how to manage it by asking them to fill out an anonymous online survey.

  Recruiting European Institute of Oncology · Milan · NCT06773650

• Using advanced imaging to detect small bowel neuroendocrine tumors

  This study is testing a new imaging method to see if it can better find small bowel neuroendocrine tumors in patients, helping doctors decide on the best treatment.

  Recruiting European Institute of Oncology · Milan · NCT06773624

• Decision-making tool to help women with early breast cancer choose treatment

  This project will test a patient decision aid to help women with early-stage breast cancer make treatment choices.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06762496

• Testing for specific mutations in metastatic breast cancer patients using liquid biopsy

  This study is testing a new blood test to see if it can find specific gene mutations in people with certain types of metastatic breast cancer to help guide their treatment.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06762483

• New algorithm for gene testing in metastatic prostate cancer using liquid biopsy

  This study is trying out a new way to test for gene mutations in the blood of men with advanced prostate cancer to see if it can improve their diagnosis and treatment.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06762379

• Assessing psychological factors in patients receiving spinal cord stimulation for chronic pain

  This study looks at how anxiety and depression affect pain relief and satisfaction in patients getting spinal cord stimulation for chronic pain.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06761300

• Cognitive screening for lung cancer patients

  This study is trying to see if lung cancer and its treatments affect thinking skills in patients during their first year after diagnosis.

  Recruiting European Institute of Oncology · Milan · NCT06727370

• Improving medication adherence for patients with metastatic breast cancer

  This study is testing a new way to help people with metastatic breast cancer remember to take their oral medications by using personalized reminders and feedback.

  Recruiting European Institute of Oncology · Milan · NCT06726889

• Evaluating HER2DX's impact on treatment decisions for early stage HER2+ breast cancer

  This study is testing how the HER2DX test affects treatment choices for patients with early stage HER2+ breast cancer to see if it helps doctors feel more confident in their recommendations.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06723990

• Improving diagnosis and treatment of head and neck cancer through epigenetic profiling

  This study is testing if looking at specific changes in genes can help doctors better diagnose and treat head and neck cancer in adults who haven't had treatment yet.

  Recruiting European Institute of Oncology · Milan, MI · NCT06706973

• Assessing PIK3CA mutations in metastatic breast cancer

  This study is testing a new way to find PIK3CA gene mutations in patients with metastatic breast cancer using both tissue samples and blood tests to see if it can help tailor treatments better.

  Recruiting European Institute of Oncology · Milan, MI · NCT06706570

• Analyzing tumor DNA in patients with low HER2 advanced breast cancer

  This study is testing if analyzing tumor DNA in patients with advanced breast cancer that has low HER2 levels can help track how the disease is progressing and how well treatments are working.

  Recruiting European Institute of Oncology · Milan, MI · NCT06706557

• Improving patient understanding of Oncotype DX test results for early breast cancer

  This study tests if an eight-minute video can help early breast cancer patients better understand their Oncotype DX test results and the risks of cancer returning compared to regular information leaflets.

  Recruiting European Institute of Oncology · Milan · NCT06703567

• Atezolizumab with cyclophosphamide and vinorelbine for metastatic triple-negative breast cancer

  This trial will test whether adding atezolizumab to the chemotherapy drugs cyclophosphamide and vinorelbine helps people with PD-L1–positive metastatic triple-negative breast cancer who are starting first-line treatment after prior PD-1/PD-L1 therapy.

  Recruiting at 2 sites Phase 2 European Institute of Oncology · Monza, Monza and 4 other locations · NCT06690840

• Fasting-mimicking diet to lower cholesterol and reduce side effects from aromatase inhibitors in breast cancer patients.

  This trial tests whether short cycles of a fasting-mimicking diet can lower total cholesterol in adults with early ER-positive breast cancer who are taking aromatase inhibitors.

  Recruiting European Institute of Oncology · Milan, Italy · NCT06610565

• Evaluating a test for cervical pre-cancer

  This study is testing a new test called PreCursor-M+ to see if it can accurately identify changes in cervical pre-cancer in women with CIN2, while they are monitored over two years.

  Recruiting European Institute of Oncology · Milan and 1 other locations · NCT06403618

• Predicting toxicity in elderly patients with head and neck cancer

  This study is trying to create a score to help doctors predict if older patients with head and neck cancer will have serious side effects from their treatment.

  Recruiting European Institute of Oncology · Milan, Milan · NCT06344208

• Young adults with gastrointestinal and neuroendocrine cancers

  This study is trying to gather samples from young adults with gastrointestinal and neuroendocrine cancers to learn more about their specific needs and improve treatment options for them.

  Recruiting European Institute of Oncology · Milan · NCT06337760

• Radiotherapy for limb neoplasms

  This study looks at how well radiotherapy works for people with tumors in their arms or legs to find the best treatment options.

  Recruiting European Institute of Oncology · Milan · NCT06335251

• Minimally invasive treatments for thyroid cancer

  This study is testing whether less invasive treatments for small thyroid cancers can safely replace surgery and improve patients' quality of life.

  Recruiting European Institute of Oncology · Milan · NCT06333587

• Exploring the role of microbiome and immune system in colorectal cancer

  This study is trying to understand how the gut bacteria and immune system affect colorectal cancer to help doctors make better treatment choices for patients.

  Recruiting European Institute of Oncology · Milan · NCT06331988

• CyberKnife treatment for localized prostate cancer

  This study is testing if a special type of radiation treatment called CyberKnife can effectively target localized prostate cancer in men who are at intermediate to high risk.

  Recruiting European Institute of Oncology · Milan · NCT06331013

• Using MRI to detect early breast cancer metastases

  This study is testing if a special type of MRI can help find early signs of breast cancer returning in high-risk patients to see if it can improve their chances of living longer.

  Recruiting European Institute of Oncology · Milan · NCT06328465

• Performance analysis of an HPV test for anal cancer screening

  This study is testing a new HPV test on anal samples to see if it can help high-risk people find anal cancer and precancerous conditions more easily.

  Recruiting European Institute of Oncology · Milan · NCT06327568

• Comparing imaging methods for prostate cancer treatment evaluation

  This study is testing whether whole body MRI is better than bone scans and CT scans for checking how well treatments are working in men with advanced prostate cancer.

  Recruiting European Institute of Oncology · Milan · NCT06321679

• Evaluating lymphedema after targeted radiotherapy for breast cancer

  This study is testing if a new type of targeted radiation therapy can help prevent arm swelling in breast cancer patients after surgery.

  Recruiting European Institute of Oncology · Milan · NCT06321653

• Cryoablation treatment for low-risk early breast cancer

  This study is testing whether a new freezing treatment for early-stage, low-risk breast cancer can be a safer and more effective option for women aged 50 and older compared to traditional surgery.

  Recruiting European Institute of Oncology · Milan · NCT06300125

• Non-surgical treatment for breast cancer after chemotherapy

  This study tests if using radiotherapy alone is a safe and effective option for breast cancer patients who have responded well to chemotherapy, instead of undergoing surgery.

  Recruiting European Institute of Oncology · Candiolo, Turin and 1 other locations · NCT06281210

• Using augmented reality to improve prostate cancer surgery outcomes

  This study is testing whether using augmented reality during prostate cancer surgery can lead to better outcomes and help preserve erectile function compared to standard surgery methods.

  Recruiting European Institute of Oncology · Milan · NCT06059859

• Understanding response to stereotactic body radiotherapy in early-stage lung cancer

  This study is trying to understand why some people with early-stage lung cancer respond better to a specific type of radiation treatment than others, to help improve future treatments.

  Recruiting at 2 sites European Institute of Oncology · Milan, Italy and 1 other locations · NCT05974475

• Collecting data on proton therapy for cancer treatment

  This study is collecting information on how well proton therapy works for cancer treatment to help improve care for patients.

  Recruiting European Institute of Oncology · Milan · NCT05860361

• Using metronomic temozolomide for patients with advanced neuroendocrine tumors who are unfit for standard treatments

  This study is testing if a continuous low-dose chemotherapy called metronomic temozolomide can help people with advanced neuroendocrine tumors who can't tolerate standard treatments feel better and live longer.

  Recruiting Phase 2 European Institute of Oncology · Milan · NCT05554003

• Preoperative radiotherapy for early stage breast cancer

  This study is testing if a single dose of targeted radiation before surgery can safely help patients with early-stage breast cancer by shrinking their tumors.

  Recruiting European Institute of Oncology · Milan · NCT04679454

• Treatment for chest wall breast cancer using pembrolizumab and cyclophosphamide

  This study is testing a combination of two medications, pembrolizumab and cyclophosphamide, to see if they can help people with breast cancer that has spread to the chest wall.

  Recruiting Phase 2 European Institute of Oncology · Milan · NCT03971045

Quick answers

How many clinical trials run by European Institute of Oncology are recruiting right now?

58, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Italy (58 trials), Switzerland (1 trial), France (1 trial), Germany (1 trial), Lithuania (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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