Improving diagnosis and treatment of head and neck cancer through epigenetic profiling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of epigenetic marks in head and neck cancer (HNC) to identify potential therapeutic targets. It focuses on distinguishing between HPV-positive and HPV-negative HNC by analyzing unique histone modifications. The research aims to understand how these epigenetic changes contribute to tumorigenesis in HNC, which could lead to more effective treatment strategies. Participants will include adults diagnosed with primary squamous cell carcinoma of the oral cavity, larynx, oropharynx, who have not received prior treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:• Age: Adults aged ≥ 18 years diagnosed with HNC

* Sex: Both male and female
* Human papilloma virus (HPV) test: Both positive and negative.
* Tumor: primary tumors, treatment naïve, squamous cell carcinoma
* Cancer stage: I-IV
* Anatomic location: oral cavity, larynx, oropharynx
* Tumor fragments not required for diagnostics

Exclusion Criteria:

* Previous radiotherapy, chemotherapy or immunotherapy for HNC
* Unable to provide written informed consent

Where it's running

• European Institute of oncology
  Milan, Mi, Italy Recruiting

Study contacts

• Principal investigator: Susanna Chiocca — Istituto Europeo di Oncologia
• Study coordinator: Susanna Chiocca, Doctor
• Email: susanna.chiocca@ieo.it
• Phone: 00390257488835

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.