Using advanced imaging to detect small bowel neuroendocrine tumors
Official title: Evaluation of 68Ga-DOTATOC PET/CT-enterography for the Detection of the Primary Lesion in Neuroendocrine Tumors of the Small Bowel
Run by European Institute of Oncology · NCT06773624 · Data updated 2026-11-12
This study is testing a new imaging method to see if it can better find small bowel neuroendocrine tumors in patients, helping doctors decide on the best treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 18 (estimated) |
| Sponsor | European Institute of Oncology Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | April 23, 2021 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | January 14, 2025 |
| Trial ID | NCT06773624 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients diagnosed with small bowel neuroendocrine tumors who are eligible for surgical resection.
✕Probably not a fit
Patients with other synchronous oncological diseases or those not eligible for surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of 68Ga-DOTATOC PET/CT-enterography in identifying primary lesions in patients with small bowel neuroendocrine tumors. The study focuses on the importance of accurate staging and evaluation of disease burden, which are critical for determining appropriate treatment options. By utilizing a radiolabeled peptide that targets somatostatin receptors, the trial aims to improve imaging techniques compared to conventional methods. The goal is to enhance the detection of metastatic disease and tumor grading, which are vital prognostic factors.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate diagnoses and better treatment planning for patients with small bowel neuroendocrine tumors.
How similar studies have gone: Other studies utilizing similar imaging techniques have shown promise, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with small bowel neuroendocrine tumours * tumors with any grade (from 1 to 3) and any Ki 67 percentage * patients eligible for surgical resection Exclusion Criteria: * patients with synchronous other oncological disease * patients with Inflammatory bowel disease * patients Not eligible for surgery
Where it's running
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European Institute of Oncology
Milan, Italy Recruiting
Study contacts
- Study coordinator: Luigi Funicelli, MD
- Email: luigi.funicelli@ieo.it
- Phone: +390294372725
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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External validation of the TB-NET score in advanced well‑differentiated neuroendocrine tumors
This study tests whether the TB-NET score can predict progression-free survival in adults with advanced well-differentiated gastroenteropancreatic neuroendocrine tumors or lung carcinoids who have received systemic therapy.
-
Ultralow-dose PET imaging of somatostatin receptor 2 (SSTR2) uptake
This study will test whether an ultralow-dose 68Ga-Dotatate PET scan on a high-sensitivity scanner can detect SSTR2 uptake in adults with and without neuroendocrine tumors.
-
How endocrine tumors develop resistance to alkylating chemotherapy
This study will test whether patients with endocrine tumors who receive alkylating chemotherapy develop high tumor mutation rates and whether blood tests and imaging can detect those changes.
-
Quality of life after surgery for neuroendocrine tumors
This study looks at how surgery for neuroendocrine tumors affects the quality of life for patients to help improve their care after the operation.
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Removal of the primary small-intestine neuroendocrine tumor versus systemic therapy alone
This project tries to see if removing the main small-intestine neuroendocrine tumor helps people with incurable metastatic disease live longer or avoid future problems, compared with treating them with systemic therapy alone.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.