Sponsor or institution
Clinical trials and research at Broad Institute, INC.
As of November 12, 2026, Find a Trial lists 253 NIH-funded research projects at this institution, with $429.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 253NIH research projects
NIH-funded research (newest 40 of 253)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Broad-Color: A Center to Accelerate All of Us Genomics
A national effort to speed up personalized medicine by expanding genomic data and clinical insight for All of Us participants.
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Common Fund data knowledge center to make big data insights easy to use
A project to make NIH Common Fund datasets easy to find, understand, and use for researchers by turning them into trusted, clearly explained knowledge that supports big data discoveries.
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Massive-scale genomic risk assessment to inform precision medicine for diabetes
A large study aims to map how genetic differences influence different forms of diabetes to guide personalized care.
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Massive-scale genetic risk profiling to guide personalized diabetes care
A large NIH-funded project will study how many diabetes-related genetic variants influence risk across diverse populations to help tailor prevention and treatment.
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Asian Bipolar Genetics Network study
This project studies the genetics of bipolar disorder in East and South Asian people to better understand risk factors and how they may affect diagnosis and care.
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Broad-Color: A Genomic Center to Accelerate All of Us for Better Health
A national genomic resource project will expand and speed up how researchers use genetic data from All of Us participants to improve understanding, diagnosis, and treatment of human diseases.
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Therapeutic editing to lower PrP in prion disease
A research program aims to lower the prion protein (PrP) in people at risk of or living with prion disease using a one-time gene-editing approach.
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Targeted beta cell therapy delivery to help people with brittle diabetes
A research program aims to develop safe, targeted ways to release therapeutic agents inside insulin-producing beta cells to support people with type 1 diabetes.
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ePACE: automated, scalable evolution of biomolecules with therapeutic potential
A team at Broad Institute is refining automated, continuous evolution methods to create biomolecules that could become new medicines or biotech tools.
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Expanding the AnVIL data system to help researchers access and analyze large genomic datasets
A national data platform is being expanded to give researchers easier and faster access to diverse genomic data across multiple cloud providers.
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Genomic data resource to accelerate pediatric disease research
This grant helps a big research center generate and share high-quality genome and RNA data from children with diseases and their families to speed discoveries that can help young patients.
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Biochemical map of how exercise changes the body
Scientists are studying how exercise changes key molecules in the blood to better understand the body’s response to physical activity.
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Common Fund Knowledge Center: turning big biomedical data into clear, usable knowledge
A project to make NIH CF datasets easy to find and trust by presenting them as clear, scientifically valid knowledge that researchers can use with confidence.
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Expansion Genomics for high-resolution single-cell and spatial epigenomics
A new plan to map the epigenome at unprecedented detail in single cells and tissues by expanding samples to reveal nanoscale features.
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Epigenetic changes in Down syndrome using human cell models
This grant studies how the epigenetic system in human cells is altered in Down syndrome and how these changes affect brain-related biology.
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Foundational resource mapping DNA elements and gene regulation to understand autoimmune diseases
A large project will map DNA elements and how genes are controlled in human cells to help interpret noncoding genetic variants linked to autoimmune diseases.
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Pathways and Molecules to Prevent Early-Onset Colorectal Tumors
A project at the Broad Institute aims to understand why colorectal cancer is increasing in people under 50 and identify ways to prevent it.
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Reprogramming cancer signaling to help treat colorectal cancer
Aims to use targeted signals to push colorectal cancer cells toward a state that makes them easier to kill, with potential benefits for patients who have this disease.
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Illumine: uncovering the hidden proteins linked to cancer
A research team is studying a mysterious group of proteins called the dark proteome to understand how they arise, how they behave in cancer, and whether they could be targeted for new treatments.
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Polygenic risk scores for diabetes and its complications across diverse populations
A study to develop and test genetic risk scores for diabetes and related complications in people from many different ancestries to improve prediction and care.
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Broad Institute’s Mendelian Genomics Center aims to harmonize long- and short-read sequencing data for rare diseases
Aims to clean up and share detailed genetic data from thousands of people with rare diseases to improve diagnosis.
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Boosting CAR T cell power in solid tumors by turning on transcription factors
A new research project tests whether turning on specific human transcription factors can make CAR T cells work better against solid tumors.
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Live, self-reported RNA signals in living cells for real-time molecular reading
This grant aims to let living cells reveal their own RNA patterns over time using a self-reporting system so researchers can study dynamic biology without destroying the cells.
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Understanding how APP processing affects Alzheimer’s disease at the single-molecule level
A new NIH grant aims to study how the amyloid precursor protein (APP) behaves in brain cells to influence Alzheimer’s disease, using advanced imaging to track single molecules.
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Computational maps of how cells talk to each other in mucosal tissues
Researchers will use computer methods to understand how different cell types in mucosal tissues communicate and change in diseases like asthma.
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Broad ClinGen Clinical Genome Resource for Cancer Variants
A study to create and improve trusted knowledge about how genetic variants relate to cancer, helping doctors and researchers use genome information in patient care.
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Targeting PRMT5 in MTAP-deleted cancers
A research project tests a new approach to treat cancers that often lose MTAP, by using PRMT5 inhibitors to selectively kill cancer cells.
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Massive-scale genomic risk insights to personalize diabetes care
A large genetics study aims to help doctors tailor care for people with diabetes by understanding how both common and rare genetic variants influence the disease.
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Genetics of PTSD in people of African ancestry
This project studies genetic factors linked to PTSD in people with African ancestry to understand why some develop PTSD after trauma.
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Scalable molecular pipelines for FAIR, reusable brain data in the BICAN network
A flexible, cloud-based system will standardize and share brain cell data across researchers to build better brain atlases.
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Expanding the AnVIL data hub to support diverse health data and research
This grant aims to grow a cloud-based data ecosystem (AnVIL) so researchers can access, share, and analyze large, diverse health and genomic datasets across multiple clouds.
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Multimodal and Generative AI for Pathology (Patient-facing overview)
A research project at a major medical center will develop advanced computer tools that help doctors interpret tissue slides more consistently and accurately, potentially improving diagnoses and treatment decisions for patients.
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Asian Bipolar Genetics Network to study BP genetics across East and South Asia
A big genetic study of bipolar disorder in people of Asian ancestry aims to find more genetic factors and understand how BP differs across populations.
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Encore: speeding up finding new uses for existing drugs to help kids with rare diseases
A big NIH project will test thousands of existing medicines to see if any can help treat rare genetic diseases in children.
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Imaging Repository to Advance Cerebrovascular Disease Knowledge
A patient-friendly imaging data resource is being created to help researchers understand brain blood vessel disorders and improve treatments for stroke and related conditions.
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Genetic clues to how mitochondrial and nuclear genes affect aging and dementia
This grant explores how the interaction between mitochondrial and nuclear genes might influence aging and diseases like Alzheimer’s dementia.
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Genetic discovery for diabetic kidney disease in adults
A scientist team is studying the genes that influence diabetic kidney disease in adults to better understand why some people develop it.
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Asian Bipolar Genetics Network
Collect genetic and health information from adults of Asian ancestry with and without bipolar disorder to look for genetic differences linked to bipolar disorder.
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Asian Bipolar Genetics Network — genetics of bipolar disorder in Asian adults
This project looks at how genetic differences contribute to bipolar disorder in adults of East and South Asian ancestry by collecting DNA and detailed clinical and life-stressor information.
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Unraveling GPCR Signals in Living Cells with Extended Single-Molecule Imaging
A new project will study how GPCR signals are produced inside living cells using advanced, long-lasting single-molecule imaging to better understand cardiovascular and related diseases.
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