Broad ClinGen Clinical Genome Resource for Cancer Variants
Official title: Broad-Geisinger Clinical Genome Resource (ClinGen)
Funded at Broad Institute, INC. · NIH-11422427 · Data updated 2026-11-12
A study to create and improve trusted knowledge about how genetic variants relate to cancer, helping doctors and researchers use genome information in patient care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 23, 2013 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $4,781,250 |
| NIH project number | 2U24HG006834-13 |
| Project ID | NIH-11422427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients with cancer whose genomic data could inform diagnosis, prognosis, or treatment decisions through high-quality variant interpretation.
✕Less likely to help
Patients whose cancer genetics do not involve the variants captured in ClinGen or who receive care where genomic data is not used may see limited direct benefit.
What this research studies
This project strengthens a centralized resource that catalogs how gene variants affect cancer, making it easier for clinicians to interpret patient genomes. It expands standards for judging which variants matter clinically and increases sharing of gene and variant data from clinicians, labs, researchers, and patients. The work includes updating tools and creating new ones to speed up high-quality, expert reviews of cancer-related genetic information. By collaborating with partner grants, it aims to scale its impact across institutions and applications in precision oncology.
Why it matters
Potential benefit: If successful, clinicians could interpret cancer genomes more accurately and quickly, improving diagnosis and personalized treatment decisions.
How similar studies have gone: Previous ClinGen efforts have established standards and data-sharing practices that improved consistency in variant interpretation, with ongoing expansion showing promise.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Rehm, Heidi L — Broad Institute, INC.
- Study coordinator: Rehm, Heidi L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.