Asian Bipolar Genetics Network
Official title: 1/4 Asian Bipolar Genetics Network (A-BIG-NET)
Funded at Broad Institute, INC. · NIH-11397173 · Data updated 2026-11-12
Collect genetic and health information from adults of Asian ancestry with and without bipolar disorder to look for genetic differences linked to bipolar disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 19, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $490,220 |
| NIH project number | 3R01MH130675-04S2 |
| Project ID | NIH-11397173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) of Asian ancestry with a diagnosis of bipolar disorder, and Asian-ancestry adults without bipolar disorder to serve as comparison participants.
✕Less likely to help
People who are not of Asian ancestry or who are under 21 are less likely to be represented and may not directly benefit from the population-specific findings.
What this research studies
This project brings together research centers across East and South Asia to build a large genetic database of people with and without bipolar disorder. If you join, you'll be asked to provide a blood or saliva sample for DNA sequencing and to share medical and life-stress information through interviews or questionnaires. Researchers will use 4x low-pass whole genome sequencing to compare common and rare genetic variants between 27,500 cases and 16,000 controls and include environmental measures. The goal is to find genetic differences that explain bipolar risk in Asian populations and help make future testing or treatments more accurate for people like you.
Why it matters
Potential benefit: Could identify genetic markers that improve diagnosis, risk prediction, or point toward new treatments for bipolar disorder in Asian populations.
How similar studies have gone: Large genetic studies in mainly European populations have successfully identified risk loci for bipolar disorder, so the methods are proven but applying them to Asian groups is novel.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Huang, Hailiang — Broad Institute, INC.
- Study coordinator: Huang, Hailiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.