Asian Bipolar Genetics Network to study BP genetics across East and South Asia
Official title: 1/4 Asian Bipolar Genetics Network (A-BIG-NET)
Funded at Broad Institute, INC. · NIH-11405506 · Data updated 2026-11-12
A big genetic study of bipolar disorder in people of Asian ancestry aims to find more genetic factors and understand how BP differs across populations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 19, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,058,879 |
| NIH project number | 5R01MH130675-05 |
| Project ID | NIH-11405506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults of Asian ancestry (including Asian Americans) and individuals with bipolar disorder or related conditions who may contribute to or benefit from genetic research.
✕Less likely to help
People who are not of Asian ancestry or who do not participate in genomic research may not directly benefit.
What this research studies
This grant brings together researchers from the U.S. and Asia to build a large genetic resource for bipolar disorder in East and South Asian populations. It will collect genetic data and rich clinical information from tens of thousands of individuals, including environmental stressors, using low-pass whole genome sequencing. The goal is to uncover population-specific genetic variants and improve our understanding of BP across diverse groups, which could inform future diagnostics and treatments for patients. The study also plans to leverage existing schizophrenia data resources to enable cross-disease insights.
Why it matters
Potential benefit: If successful, the research could lead to more precise risk assessment and personalized approaches for bipolar disorder in Asian populations.
How similar studies have gone: Previous large genetic studies in BP have identified some loci, but results in Asian populations are still limited, making this a novel and impactful effort in this population.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Huang, Hailiang — Broad Institute, INC.
- Study coordinator: Huang, Hailiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.