Massive-scale genomic risk insights to personalize diabetes care
Official title: Massive-scale genomic risk assessment to inform precision medicine across the spectrum of monogenic and common forms of diabetes
Funded at Broad Institute, INC. · NIH-11417985 · Data updated 2026-11-12
A large genetics study aims to help doctors tailor care for people with diabetes by understanding how both common and rare genetic variants influence the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 19, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $668,223 |
| NIH project number | 5R01DK140545-02 |
| Project ID | NIH-11417985 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for type 1, type 2, or monogenic diabetes, including people from diverse ancestral backgrounds.
✕Less likely to help
People without a genetic variant linked to diabetes or those not undergoing genetic testing may not experience direct benefits.
What this research studies
This project analyzes how many genetic differences relate to type 1, type 2, and monogenic forms of diabetes across diverse populations. It seeks to create a unified framework for interpreting and reporting genetic variants to improve diagnostic accuracy and patient guidance. Researchers will integrate large genetic datasets with clinical information to clarify variant effects and support precision medicine for people with diabetes and their families.
Why it matters
Potential benefit: If successful, the work could lead to clearer genetic testing results and more personalized diabetes treatment plans.
How similar studies have gone: Previous studies show genetic testing can inform diabetes classification and care, with ongoing improvements in interpretation guidelines.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Mercader, Josep Maria — Broad Institute, INC.
- Study coordinator: Mercader, Josep Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.