Foundational resource mapping DNA elements and gene regulation to understand autoimmune diseases
Official title: A Foundational Resource of Functional Elements, TF footprints and Gene Regulatory Interactions
Funded at Broad Institute, INC. · NIH-11514948 · Data updated 2026-11-12
A large project will map DNA elements and how genes are controlled in human cells to help interpret noncoding genetic variants linked to autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 9, 2021 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,220,877 |
| NIH project number | 3UM1HG011986-05S1 |
| Project ID | NIH-11514948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with autoimmune diseases or those whose genetic data are being analyzed for disease risk and mechanism.
✕Less likely to help
Individuals without autoimmune disease or without interest in genomic interpretation may see limited direct benefit.
What this research studies
This project will create a foundational resource of functional DNA elements, transcription factor binding sites, and gene regulatory interactions using single-cell assays. It focuses on understanding how noncoding genetic differences influence disease by identifying where, when, and how these variants affect gene regulation in relevant cell types and states. The work aims to enable researchers to interpret disease-associated variants and accelerate genomic medicine related to autoimmune diseases.
Why it matters
Potential benefit: If successful, clinicians and patients may benefit from sharper insights into how genetic variation contributes to autoimmune diseases, potentially guiding future diagnostics and personalized therapies.
How similar studies have gone: Previous genome-wide maps of regulatory elements have improved interpretation of noncoding variants, and this project extends those resources to disease-relevant contexts.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Buenrostro, Jason Daniel — Broad Institute, INC.
- Study coordinator: Buenrostro, Jason Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.