Asian Bipolar Genetics Network study
Official title: 1/4 Asian Bipolar Genetics Network (A-BIG-NET)
Funded at Broad Institute, INC. · NIH-11590785 · Data updated 2026-11-12
This project studies the genetics of bipolar disorder in East and South Asian people to better understand risk factors and how they may affect diagnosis and care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 19, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $7,984 |
| NIH project number | 3R01MH130675-05S1 |
| Project ID | NIH-11590785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) of Asian ancestry, including those who are affected by bipolar disorder and healthy controls for comparison.
✕Less likely to help
Individuals without bipolar disorder or not of Asian ancestry may not directly benefit from this study.
What this research studies
Bipolar disorder is a serious mental health condition with a complex genetic background. A-BIG-NET will collect genetic data from about 27,500 individuals with bipolar disorder and 16,000 controls, along with detailed environmental and clinical information. Researchers will use low-pass whole-genome sequencing to build a large, shared resource that can be studied for how genes and environment contribute to bipolar risk in Asian populations. The study is conducted by an international team at the Broad Institute and collaborating institutions in the U.S. and Asia. Results may guide future research and potentially inform more personalized approaches to care for people with bipolar disorder of Asian ancestry.
Why it matters
Potential benefit: Could lead to better understanding of bipolar disorder in Asian populations and pave the way for more personalized diagnostics and treatments.
How similar studies have gone: Prior genetic studies identified several risk loci, but this project aims to expand findings in underrepresented populations with a much larger dataset.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Huang, Hailiang — Broad Institute, INC.
- Study coordinator: Huang, Hailiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.