Unraveling GPCR Signals in Living Cells with Extended Single-Molecule Imaging
Official title: Unraveling Signal Transduction: Extended Single-Molecule Visualization in Living Cells
Funded at Broad Institute, INC. · NIH-11395732 · Data updated 2026-11-12
A new project will study how GPCR signals are produced inside living cells using advanced, long-lasting single-molecule imaging to better understand cardiovascular and related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $831,250 |
| NIH project number | 1DP2EB041715-01 |
| Project ID | NIH-11395732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with cardiovascular diseases or at risk, whose condition could be linked to GPCR signaling pathways.
✕Less likely to help
Individuals without cardiovascular or related diseases may not directly benefit from this basic discovery effort.
What this research studies
This project aims to watch individual GPCR proteins live in cells over extended periods to understand how they start and control signaling. By using novel fluorescence methods that stay bright longer, researchers can capture the sequence of events that short-lived probes miss. The goal is to connect precise molecular dynamics to broader cardiovascular and related disease processes. Results could uncover new ways to influence GPCR signaling with therapies. The work blends cutting-edge imaging with cellular biology to illuminate real-time protein behavior.
Why it matters
Potential benefit: If successful, the research could reveal mechanisms of GPCR signaling that lead to new therapeutic targets for cardiovascular diseases.
How similar studies have gone: Previous single-molecule imaging studies have shown promise in revealing dynamic protein interactions, but longer-duration, live-cell observations are still developing.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Peng, Chunte — Broad Institute, INC.
- Study coordinator: Peng, Chunte
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.