Expansion Genomics for high-resolution single-cell and spatial epigenomics
Funded at Broad Institute, INC. · NIH-11531190 · Data updated 2026-11-12
A new plan to map the epigenome at unprecedented detail in single cells and tissues by expanding samples to reveal nanoscale features.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 19, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $818,165 |
| NIH project number | 7R01HG013679-02 |
| Project ID | NIH-11531190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians working on development, aging, and disease who could apply expanded-genomics methods to human samples or disease models.
✕Less likely to help
Direct patient benefit is unlikely for participants in this non-clinical research project, as it does not involve patient recruitment.
What this research studies
This project aims to dramatically improve how we study the epigenome by physically expanding cells and tissues so that existing single-cell and spatial profiling methods can see much finer details. It combines expansion with current techniques like ATAC-seq, CUT&Tag, and in situ genome sequencing to achieve high-throughput, multi-modal measurements without complex devices. The work focuses on making these advances accessible to many labs, potentially accelerating discoveries about development, aging, and disease. If successful, expanded-genomics methods could become standard tools for understanding gene regulation in health and illness.
Why it matters
Potential benefit: If successful, patients could benefit from more precise maps of gene regulation in diseases, leading to later diagnostics and targeted therapies.
How similar studies have gone: Preliminary methods like ATAC-seq and in situ genome sequencing have shown promise; expansion-based approaches are an emerging area with potential but require validation.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Buenrostro, Jason Daniel — Broad Institute, INC.
- Study coordinator: Buenrostro, Jason Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.