Condition

Wound clinical trials and research

• 16Clinical trials
• 224NIH research projects
• 12Countries

Newest Wound clinical trials

All recruiting trials (16)

• Cold plasma treatment for chronic wounds in adults

  This study tests whether cold plasma applied with helium and dressings infused with plasma-induced ions can help healing in adults with chronic leg or other vascular wounds.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans · NCT07564739

• Miro3D tissue scaffold for complex soft-tissue wounds and pressure ulcers

  This trial will test whether adding the Miro3D tissue scaffold to usual wound care helps adults with complex soft-tissue wounds or chronic pressure ulcers heal faster over 12 weeks.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07347106

• Cyanoacrylate glue versus collagen sponge for healing palatal donor wounds

  This test compares cyanoacrylate glue (PeriAcryl) and collagen sponge to see which helps adult patients' palatal donor sites heal faster and feel more comfortable after a free gingival graft.

  Recruiting Early Phase 1 Beirut Arab University · Beirut · NCT07086482

• Amnion grafts for hard-to-heal diabetic foot and venous leg ulcers

  This study will test whether two types of amnion grafts, added to standard wound care, help hard-to-heal diabetic foot and venous leg ulcers heal better.

  Recruiting at 7 sites Capsicure, LLC · Oxnard, California and 6 other locations · NCT07046767

• Using Negative Pressure Therapy to Prevent Infections in Surgical Wounds

  This study is testing if using Negative Pressure Therapy can help prevent infections in surgical wounds for people who have had laparotomy surgery.

  Recruiting Gulab Devi Hospital · Lahore, Punjab Province · NCT06957964

• Using botulinum toxin injections to improve blood flow and heal severe leg ulcers

  This study tests whether botulinum toxin injections can help improve blood flow and heal severe leg ulcers in older patients or those with diabetes.

  Recruiting Phase 4 Yonsei University · Yongin-si, Gyeonggi-do · NCT06878482

• New methods to reduce itching from burn scars

  This study is testing whether diphenhydramine, famotidine, and cromolyn sodium can help adults with burn scars feel less itchy.

  Recruiting Phase 3 The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT06801626

• New gel treatment for venous leg ulcers

  This study is testing a new gel treatment for people with stubborn venous leg ulcers to see if it helps them heal better than just the usual care.

  Recruiting at 5 sites Phase 3 TR Therapeutics · Jacksonville, Florida and 11 other locations · NCT06707103

• Evaluating the 3M V.A.C. Peel and Place Dressing for Wound Treatment

  This study is testing if the 3M V.A.C. Peel and Place dressing helps people with different types of wounds heal better when used with 3M V.A.C. Therapy.

  Recruiting at 3 sites Solventum US LLC · Indianapolis, Indiana and 2 other locations · NCT06625385

• Alb-PRF vs PRF to reduce pain and improve healing after palate graft harvesting

  This trial will test whether Alb-PRF or PRF placed on the palate lowers pain and speeds healing for adults having a free gingival graft.

  Recruiting at 2 sites Cairo University · Cairo, Cairo Governorate and 2 other locations · NCT06567548

• Comparing palatal wound healing in diabetic and non-diabetic patients

  This study is testing how well wounds in the mouth heal in people with diabetes compared to those without diabetes after surgery to fix gum issues.

  Recruiting at 2 sites Universidade Estadual Paulista Júlio de Mesquita Filho · São José dos Campos, São Paulo and 1 other locations · NCT06540690

• Evaluating ENERGI-F703 GEL for diabetic foot ulcers

  This study is testing if a new gel can help heal diabetic foot ulcers that haven't improved for at least four weeks.

  Recruiting at 24 sites Phase 3 Energenesis Biomedical Co., Ltd. · Miami, Florida and 23 other locations · NCT05930210

• Robot-assisted reconstruction after surgery for rectal or anal cancer

  This study is testing if using a muscle flap to rebuild the pelvic floor or vagina after robotic surgery for rectal or anal cancer can improve recovery and quality of life for patients.

  Recruiting Oslo University Hospital · Oslo · NCT05689775

• Tracking the healing of chronic wounds with a special dressing

  This study is testing a special dressing called Mepilex Up to see if it helps people with chronic wounds, like venous leg ulcers and diabetic foot ulcers, heal better over six weeks.

  Recruiting at 4 sites Molnlycke Health Care AB · Castro Valley, California and 3 other locations · NCT05588583

• Using Oasis ECM to treat donor site wounds

  This study is testing if a new treatment called Oasis ECM can help heal donor site wounds better than regular wound care for people over 16 in the UK.

  Recruiting Cook Biotech Incorporated · Manchester, England · NCT04079348

• Using negative pressure therapy to reduce infections after vascular surgery

  This study is testing if a special type of wound therapy can help prevent infections in patients after they have vascular surgery.

  Recruiting Skane University Hospital · Malmö · NCT01913132

NIH-funded research (newest 40 of 224)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Diabetic Foot Ulcer Healing Network at the University of Arizona

  A NIH-supported project at the University of Arizona aims to improve healing of diabetic foot ulcers by studying biomarkers and running high-quality clinical trials.

  NIH research University of Arizona · Tucson, United States · NIH-11565734

• Understanding how skin layers coordinate healing after injury

  Researchers are studying how different layers of adult skin coordinate rapid healing after injury to prevent infection and chronic wounds.

  NIH research University of Washington · Seattle, United States · NIH-11499214

• Immunomodulatory therapy to speed up healing after oral cavity injuries in kids

  A new approach using a drug called FTY720 aims to improve healing and reduce pain after oral injuries or palate surgery in children.

  NIH research Old Dominion University · Norfolk, United States · NIH-11472773

• How diabetic wounds let Group B Streptococcus cause infections

  Researchers are learning how high blood sugar, immune changes, and other bacteria in diabetic wounds help Group B Streptococcus grow and cause worse infections in people with diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11461002

• Understanding how skin cells exchange harmful chemicals to cause injury and wound repair

  A research project aims to uncover how certain chemical agents damage human skin and what happens in the early stages of blistering and inflammation.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11451670

• Intestinal mucosal wound healing in humans

  A patient-friendly look at how the lining of the gut repairs itself after injury and why this matters for conditions like inflammatory bowel disease.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11446853

• GBS Group B Strep System in Diabetic Wounds and how it affects healing

  A small NIH grant is exploring how a specific bacteria, Group B Streptococcus, behaves in diabetic foot ulcers and what makes these wounds harder to heal.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11441080

• Aiming to slow dangerous lung inflammation to help fight bacterial infections like tuberculosis

  A patient-facing program tests whether stopping a specific inflammatory cell (Spp1+ macrophages) from overreacting can help control tuberculosis and possibly improve outcomes in other inflammatory diseases.

  NIH research Washington University · Saint Louis, United States · NIH-11436386

• Engineered protein materials to study wound healing and blood vessels

  A researcher team at the University of New England is studying how the environment around a protein changes its behavior to better understand wound healing and blood vessel formation.

  NIH research University of New England · Biddeford, United States · NIH-11429158

• Understanding how healing tissue uses tiny messengers and scaffolds to repair wounds

  A study to learn how cells talk to each other and how tiny vesicles and the extracellular matrix help skin wounds heal better.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11425396

• Biofilm and the body’s defense in diabetic wound healing

  Aimed at understanding how stubborn biofilm infections in diabetic wounds affect healing, this project looks at how immune cells react to biofilms in people with diabetes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11425160

• Understanding how immune and skin cells work together to repair wounds in living animals

  This NIH grant looks at how skin and immune cells cooperate to restore the skin barrier after injury, with the goal of better healing and preventing cancer progression.

  NIH research Michigan State University · East Lansing, United States · NIH-11416626

• Commensal fungi help gut wound healing by changing host metabolites

  This project looks at how natural gut fungi help wounds in the intestinal lining heal by altering body metabolites, potentially guiding new treatments for inflammatory bowel disease.

  NIH research Washington University · Saint Louis, United States · NIH-11411173

• MOSAIC II: MAP Wound Matrix to speed graft readiness after non-melanoma skin cancer surgery

  A randomized trial tests a moldable wound scaffold (MAP Wound Matrix) to speed healing and time to graft-ready skin after head and neck cancer surgeries in adults.

  NIH research Tempo Therapeutics, INC. · San Diego, UNITED STATES · NIH-11406980

• Hormone signals and sex differences in how wounds heal

  This grant explores how male- and female-specific hormones affect wound healing and scarring, with the goal of improving treatments for people who heal poorly.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11401209

• Therapeutic extracellular vesicles to boost skin wound healing

  A research grant is exploring how tiny cell messengers called extracellular vesicles can be engineered to improve skin wound repair in injury models.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11396458

• Understanding how RNA guides wound healing and regeneration in adults

  This NIH grant explores how RNA-related signals coordinate healing and tissue repair in adults who have wounds or injuries.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11393845

• How sex hormones like testosterone and estrogen change wound healing and scarring

  This project looks at how testosterone and estrogen change the way wounds heal and form scars so future care can be better matched to men and women.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11393563

• Synthetic Melanin to Help Wounds Heal Faster

  A study testing a synthetic melanin-like compound applied to skin wounds to speed healing after chemical burns in humans.

  NIH research Northwestern University · Chicago, United States · NIH-11391301

• Understanding how skin detects and closes wounds in a two-layer skin model

  Researchers are studying how skin cells sense wounds and work together to seal them, using zebrafish embryos to learn ways to improve healing in humans.

  NIH research New York University School of Medicine · New York, United States · NIH-11387767

• Ultrasound-powered therapy to boost antibiotics for tough, biofilm-covered wounds

  A doctor-research team is testing ultrasound-triggered delivery using phase-change contrast agents to help antibiotics treat chronic, biofilm-filled wounds.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11385540

• Multicomponent hydrogels to promote hair growth and scarless wound healing

  A researcher at UPenn is testing a special gel to help human-like wounds heal with hair follicles and fewer scars.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11385362

• Bioresorbable polyurethane wound dressings for diabetic skin ulcers

  A study to develop a new fully synthetic, ROS-responsive wound dressing to help healing in adults with diabetes who have nonhealing skin wounds.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11384448

• MBVs: Tiny Messengers in Skin, Bladder, and Tissue Repair

  Aims to understand how matrix-bound nanovesicles help rebuild tissue after injury, using human stem cells and 3D materials.

  NIH research University of California Santa Barbara · Santa Barbara, United States · NIH-11382928

• Role of a skin-healing gene locus in speeding wound repair

  A study at UC Irvine will explore how a specific genetic region near the FAAH gene may make skin wounds heal faster with less scarring, with potential ideas for new therapies.

  NIH research University of California-Irvine · Irvine, United States · NIH-11382807

• Understanding how mechanical forces affect diabetic wound healing

  This NIH grant supports research to learn how physical forces influence healing of diabetes-related skin wounds, with the goal of improving outcomes for people who have diabetes.

  NIH research Stanford University · Stanford, United States · NIH-11380664

• Langerhans Cells and Nociception in Burn Wounds

  Researchers are studying how nerve signals and a skin immune cell type called Langerhans cells interact to influence healing and itch/pain after burns, using mouse models.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11377584

• Predicting obesity-related diabetes and wound healing with math models

  A math-based model is being built to better understand how obesity drives type 2 diabetes and slow wound healing in adults.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-11377524

• Neural signals in surgical wound healing and how regional anesthesia changes them

  Researchers are studying how nerve signals and the immune system interact after surgery and how regional anesthesia might improve healing.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11377380

• Biomaterial Models of Ancestral Contributions to Wound Healing

  Researchers are studying how ancestry may influence skin wound healing using lab models to uncover clues for more personalized therapies.

  NIH research Univ of Maryland, College Park · College Park, United States · NIH-11376545

• CD74 and Mucosal Wound Healing

  A study at the University of Florida looks at how the CD74 protein helps mucosal healing after injuries like surgery or infection, aiming to find ways to improve recovery.

  NIH research University of Florida · Gainesville, United States · NIH-11370161

• New insights into how corneal nerves support healing to help neurotrophic keratopathy patients

  Aimed at understanding how corneal nerves and their supporting Schwann cells keep the corneal surface healthy, with the goal of developing topical therapies for neurotrophic keratopathy.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11369632

• Why skin and mouth wounds heal slowly in diabetes

  This project tests a targeted drug (MM-102) to help adults with type 1 or type 2 diabetes heal skin and oral wounds more normally.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11367549

• Bacteria-responsive hydrogel that releases antibiotics and probiotics for chronic wound infections

  A bacteria-triggered hydrogel dressing delivers antibiotics and helpful probiotics directly to chronic wounds, aiming to fight resistant bacteria and promote healing.

  NIH research Brown University · Providence, United States · NIH-11365476

• New electric-current treatment to tackle stubborn wound infections

  A new electrical therapy is being tested to help treat chronic wounds infected with biofilms so they heal faster and reduce the need for repeated antibiotics.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11362534

• Engineered Tiny Oil Droplets to Fight Wound Biofilm Infections

  A patient-focused approach using specially designed polymer nanoemulsions to tackle stubborn, antibiotic-resistant wound infections caused by biofilms.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11360181

• Exosomes and skin healing in diabetes

  A study exploring how tiny vesicles from skin cells communicate with immune cells to improve healing of diabetic wounds.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11360166

• Neutrophil diversity and flexibility in healing burn injuries

  A study exploring how different neutrophil types behave during burn wound healing and whether blood neutrophils can signal how well a wound will recover.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11357664

• Phage-Protein Nanoparticles to Treat Hard-to-Reach Wound Biofilms

  A new approach uses virus-carrying nanoparticles to penetrate and kill bacteria in stubborn wound biofilms where traditional antibiotics often fail.

  NIH research University of Massachusetts Amherst · Hadley, United States · NIH-11348260

• Immunomodulatory nanofiber gel to help chronic wounds heal faster

  A research team is testing a tiny, advanced gel made of nanofibers and peptides to steer immune cells toward healing so chronic wounds can close sooner.

  NIH research Terasaki Institute for Biomedical Innovation · Woodland Hills, UNITED STATES · NIH-11347242

Related topics

Quick answers

How many Wound clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (7 trials), Australia (1 trial), Pakistan (1 trial), Taiwan (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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