Alb-PRF vs PRF to reduce pain and improve healing after palate graft harvesting
Clinical Comparison of Albumin Platelet Rich- Fibrin (Alb-PRF) Versus Platelet-rich Fibrin (PRF) on Postoperative Morbidity Following Free Gingival Graft Harvesting: A Randomized Controlled Clinical Trial
This trial will test whether Alb-PRF or PRF placed on the palate lowers pain and speeds healing for adults having a free gingival graft.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 39 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 3 sites (Cairo, Cairo Governorate and 2 other locations) |
| Trial ID | NCT06567548 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial will enroll 39 adult participants at Cairo University and follow them for 28 days after free gingival graft (FGG) harvesting. Participants will be randomly assigned to one of three groups: Alb-PRF applied to the palatal donor site, PRF applied to the donor site, or an absorbable gelatin sponge as control. Procedures include standard FGG harvesting under local anesthesia and preparation of autologous blood products from a 10 ml venous draw. Outcomes focus on postoperative morbidity at the donor site including pain, bleeding, and wound healing over the one-month follow-up.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 who are medically healthy, non-smokers, need a free gingival graft, and can attend a one-month follow-up at Cairo University.
Not a fit: Patients who smoke, are pregnant or lactating, have poor oral hygiene, or had prior periodontal surgery in the area are excluded and are unlikely to benefit from enrollment in this protocol.
Why it matters
Potential benefit: If successful, the intervention could reduce postoperative pain and improve palatal wound healing after gingival graft harvesting.
How similar studies have performed: Conventional PRF has shown benefits for oral wound healing in prior dental studies, while Alb-PRF is a newer modification with limited but promising preliminary data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients in need of free gingival graft 2. Medically free patients 3. Adult patients above 18 years old. 4. Patients accepting a 1-month follow-up period (cooperative patients). 5. Patients who will provide an informed consent. Exclusion Criteria: 1. Smokers 2. Pregnant and lactating women 3. Patients with poor oral hygiene 4. Patients who had previous periodontal surgery in the area of interest
Where this trial is running
Cairo, Cairo Governorate and 2 other locations
- Cairo University — Cairo, Cairo Governorate, Egypt (Not_yet_recruiting)
- Cairo University — Cairo, Cairo Governorate, Egypt (Recruiting)
- Cairo University — Giza, Cairo Governorate, Egypt (Recruiting)
Study contacts
- Study coordinator: Samar Idris Hamadelnil Idris Samar Idris, master
- Email: samar.Idris@dentistry.cu.edu.eg
- Phone: 01273600331
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.