Intestinal mucosal wound healing in humans
Official title: Intestinal mucosal wound resealing
Funded at University of Michigan at Ann Arbor · NIH-11446853 · Data updated 2026-11-12
A patient-friendly look at how the lining of the gut repairs itself after injury and why this matters for conditions like inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 1998 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $726,274 |
| NIH project number | 2R01DK055679-25A1 |
| Project ID | NIH-11446853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory bowel diseases or recent intestinal injury who may contribute tissue samples or participate in future related studies.
✕Less likely to help
Individuals without gut injury or inflammatory conditions may not directly benefit from this specific mechanistic research.
What this research studies
This project studies how the gut lining mends itself after injury, focusing on the roles of oxygen levels, reactive molecules, and healing proteins. Researchers will explore how early damage signals trigger repair processes in the intestinal epithelium and how these signals influence inflammation and recovery. The work uses human-relevant biology to understand the sequence of events that restore barrier function after wounds. Findings could point to new ways to support healing in patients undergoing surgery or suffering from gut diseases.
Why it matters
Potential benefit: If successful, the research could lead to better strategies to promote gut healing and reduce complications for people with inflammatory bowel disease or after surgery.
How similar studies have gone: Past work has shown that oxygen-related signaling and specific proteins influence tissue repair, supporting the relevance of this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Nusrat, Asma — University of Michigan at Ann Arbor
- Study coordinator: Nusrat, Asma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.