Cyanoacrylate glue versus collagen sponge for healing palatal donor wounds
Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing After Harvesting a Free Gingival Graft: a Randomized Controlled Clinical Trial
This test compares cyanoacrylate glue (PeriAcryl) and collagen sponge to see which helps adult patients' palatal donor sites heal faster and feel more comfortable after a free gingival graft.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 22 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beirut Arab University Academic / other |
| Locations | 1 site (Beirut) |
| Trial ID | NCT07086482 on ClinicalTrials.gov |
What this trial studies
This single-center interventional Early Phase 1 trial at Beirut Arab University compares cyanoacrylate tissue adhesive (PeriAcryl) to a collagen sponge for managing palatal donor wounds after free gingival graft harvesting. Eligible healthy adult patients are assigned to either PeriAcryl applied over the wound or a collagen sponge stabilized with sutures, then followed at scheduled visits to monitor healing and complications. Primary outcomes are wound healing and re-epithelialization, while secondary outcomes include patient satisfaction and oral-health–related quality of life. Clinical exams and patient-reported measures will document healing speed, postoperative symptoms, and any adverse events.
Who should consider this trial
Good fit: Adults in good general health (ASA I-II) who need a free gingival graft, have healthy gingiva with low plaque and bleeding scores, and can attend follow-up visits are ideal candidates.
Not a fit: Patients with systemic diseases, coagulation disorders, heavy smokers (>10 cigarettes/day), pregnant or lactating individuals, or those with relevant drug/allergy issues are unlikely to benefit and are excluded.
Why it matters
Potential benefit: If successful, PeriAcryl could speed palatal wound healing, reduce postoperative pain and complications, and improve patient comfort after graft harvesting.
How similar studies have performed: Cyanoacrylate adhesives have been used successfully for oral soft-tissue closure in prior reports, but randomized comparisons specifically against collagen sponge for palatal donor sites are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Low-moderate anesthetic risk (ASA I-II) * No restriction on ethnicity or gender * Patients requiring FGG from the palate for periodontal plastic surgery * Clinically healthy gingiva after phase I therapy * Full-mouth plaque index grades 0 and 1 * Bleeding scores \<15% Exclusion Criteria: * Patients who smoke \> 10 cigarettes/day * Patients with coagulation disorders * Systemic diseases * Patients on certain medications that may affect periodontal tissues * Pregnant and lactating patient * Patients with allergies to drugs that will be prescribed during the treatment phase * Pathological mental conditions (dementia, psychosis) and lack of cooperation * Excessive gag reflex
Where this trial is running
Beirut
- Beirut Arab University — Beirut, Lebanon (Recruiting)
Study contacts
- Study coordinator: Dania EL Rostom, MSc Oral and Dental Surgery
- Email: daniarostom1999@hotmail.com
- Phone: +96171659355
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.