New methods to reduce itching from burn scars

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of diphenhydramine, famotidine, and cromolyn sodium in alleviating itch associated with burn scars. Participants will be divided into two groups to compare the effects of oral diphenhydramine with either a placebo or with famotidine and topical cromolyn sodium. The goal is to determine if these medications can significantly reduce itchiness in adults suffering from burn scars. The study is designed to provide insights into new treatment options for this common and distressing symptom.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Participants must meet all the inclusion criteria in order to be eligible to participate in the study.

* Participant has provided informed consent in a manner approved by the IRB and is willing and able to comply with the trial procedures.
* Adults: ≥18 to \<80 years of age.
* Has an itchy burn scar.

Exclusion Criteria:

Participants meeting any of the exclusion criteria at baseline will be excluded from study participation.

* Failure to obtain consent or unable to return for follow up assessments.
* Patient is unable to follow the protocol required assessments.
* Member of a vulnerable class (e.g., prisoners, pregnant participant, etc.).
* Any medical condition that, in the opinion of the investigator or physician, would place the participant at increased risk for participation.
* Concurrent participation in another interventional clinical trial (to avoid confounding factors that may influence outcomes).
* History of prior non-compliance or the presence or history of psychiatric condition (including drug or alcohol addiction) that would, in the opinion of the investigator, make it difficult for the participant to comply with the study procedures or follow the investigators instructions.
* Age \< 18 or ≥ 80 years.
* Taking one of the following medications: cefuroxime, dasatinib, delavirdine, neratinib, pazopanib, risedronate, or tizanidine.
* Has a pre-existing inflammatory or itchy skin disease.
* Is taking an H2 antihistamine for another indication.

Where it's running

• University of Texas Medical Branch, Galveston
  Galveston, Texas, United States Recruiting

Study contacts

• Principal investigator: Celeste Finnerty, PhD — University of Texas Medical Branch, Galveston
• Study coordinator: Celeste Finnerty, PhD
• Email: ccfinner@utmb.edu
• Phone: 409-692-9036

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.